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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/20103

Title: Immunophenotype of Mouse Cerebral Hemispheres-derived Neural Precursor Cells
Authors: Poulatsidou, K.N.
Lagoudaki, R.
Touloumi, O.
Kesidou, E.
Boziki, M.
Ravanidis, Stelios
Chlichlia, K.
Grigoriou, M.
Grigoriadis, N.
Issue Date: 2015
Citation: NEUROSCIENCE LETTERS, 611, p. 33-39
Abstract: Postnatally isolated neural precursor cells (piNPCs) from mouse cerebral tissue have been studied in cell-based therapeutic approaches for Experimental Autoimmune Encephalomyelitis (EAE). Transplantation experiments in EAE rodents revealed that piNPCs manage to integrate into the host tissue and ameliorate clinical symptoms. When cultured in vitro, mouse cerebral piNPCs form neurospheres consisting of immature cells positive for polysialylated neural adhesion molecule (PSA-NCAM) that differentiate mainly towards glial cells, but also neurons. Herein, we have characterized piNPCs immunophenotype, with flow cytometry. NPCs were positive for CD24, CD44, and CD133 though negative for CD15, CD184 and CD49d. This immunophenotype, determined for the first time, among cells isolated from neonates might be useful for the identification of NPC population aiming at the development of transplantation protocols.
Notes: Grigoriadis, N (reprint author), Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Neurol B, Lab Expt Neurol & Neuroimmunol, Thessaloniki 54636, Greece. grigoria@med.auth.gr
URI: http://hdl.handle.net/1942/20103
DOI: 10.1016/j.neulet.2015.11.011
ISI #: 000368952000006
ISSN: 0304-3940
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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