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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/1996

Title: Correlation of postmortem 9.4 tesla magnetic resonance imaging and immunohistopathology of the human thoracic spinal cord 7 months after traumatic cervical spine injury
Authors: Scholtes, F.
Adriaensens, Peter
Storme, Liesbet
Buss, A.
Kakulas, B.A.
Gelan, Jan
Beuls, Emile
Schoenen, J.
Brook, G.A.
Martin, Didier
Issue Date: 2006
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Citation: NEUROSURGERY, 59(3). p. 671-677
Abstract: OBJECTIVE: To correlate high-resolution magnetic resonance imaging (MRI) with immunohistopathology in the injured human spinal cord. METHODS: Postmortem MRI scans at a field strength of 9.4 T, as well as standard histology and immunohistochemistry, were performed on an excised specimen of human high thoracic spinal cord, obtained 7 months after the initial trauma, several segments below a severe spinal cord lesion (C5). RESULTS: A precise correlation is described between MRI and immunohistochemistry of the long white matter tracts undergoing Wallerian degeneration and of an extension of the cervical lesion into the high thoracic cord. CONCLUSION: MRI, the only imaging technique that currently provides useful information on the spinal cord parenchyma after trauma, is rapidly evolving. High-field scanners of up to 9.4 T are being clinically tested. The present Postmortem investigation of an isolated spinal cord specimen demonstrates the precise correlation that can be achieved between imaging and pathology. In future investigations, this type of technique can lead to a more precise description of spinal cord injuries and their consequences in remote tissue. Translation into the clinical setting will improve diagnosis and follow-up of spinal cord injured patients.
Notes: Ctr Hosp Univ, Dept Neurosurg, B-4000 Liege, Belgium. Univ Liege, Dept Neuroanat, Ctr Cellular & Mol Neurobiol, Liege, Belgium. Hasselt Univ, Dept Chem, Diepenbeek, Belgium. Hasselt Univ, Dept Biol, Diepenbeek, Belgium. Hasselt Univ, Dept Geol, Diepenbeek, Belgium. Rhein Westfal TH Aachen, Dept Neurol, D-5100 Aachen, Germany. Univ Western Australia, Dept Neuropathol, Perth, WA 6009, Australia. Royal Perth Hosp, Perth, WA, Australia. Univ Maastricht, Dept Neurosurg, Maastricht, Netherlands. Univ Liege, Dept Neuroanat, Ctr Cellular & Mol Neurobiol, Liege, Belgium.Martin, D, Ctr Hosp Univ, Dept Neurosurg, Sart Tilman B35, B-4000 Liege, Belgium.Didier.Martin@chu.ulg.ac.be
URI: http://hdl.handle.net/1942/1996
Link to publication: http://www.neurosurgery-online.com/pt/re/neurosurg/abstract.00006123-200609000-00020.htm;jsessionid=H7bR80mYcPw6fSp8dwMhQmwlp5pNzdW91gKGPQjcczxb09YfVMBn!-2026113843!181195628!8091!-1
ISI #: 000240623900039
ISSN: 0148-396X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2007
Appears in Collections: Research publications

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