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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/1990

Title: Effects of IFN-beta, leptin and simvastatin on LIF secretion by T lymphocytes of MS patients and healthy controls
Authors: VANDERLOCHT, Joris
HENDRIKS, Jerome
VENKEN, Koen
STINISSEN, Piet
HELLINGS, Niels
Issue Date: 2006
Publisher: ELSEVIER SCIENCE BV
Citation: JOURNAL OF NEUROIMMUNOLOGY, 177(1-2). p. 189-200
Abstract: In multiple sclerosis (MS), oligodendrocyte injury is believed to be caused by an aberrant immune response initiated by autoreactive T cells. Increasing evidence indicates that inflammatory responses in the central nervous system are not exclusively detrimental, but may also exert protective effects. Such protective effects are potentially mediated by the local secretion of neurotrophic factors by immune cells. We previously reported that T cells and monocytes in vitro and in inflammatory MS lesions produce leukaemia inhibitory factor (LIF), a member of the neuropoietic family of neurotrophins. In the present study, we report a reduced LIF production by CD4(+) T cells of relapsing remitting MS patients as compared to healthy controls. Furthermore, immunomodulatory agents such as leptin, IFN-beta and simvastatin were studied for their potential to alter LIF and secretion of other cytokines by T cells and monocytes of relapsing remitting MS patients and healthy controls. Low doses of simvastatin, but not IFN-beta or leptin enhanced LIF secretion by CD4+ T cells of RR-MS patients. We further demonstrated that LIF did not influence viability, proliferation and cytokine secretion of T cells. Together these data provide new information on the regulation of LIF secretion by immune cells. Further insights into the complex regulation of neurotrophic factors such as LIF may prove useful for treatment of MS. (c) 2006 Elsevier B.V All rights reserved.
Notes: Hasselt Univ, Biomed Onderzoeksinst, B-3590 Diepenbeek, Belgium. Trasnatl Univ Limburg, Sch Life Sci, Diepenbeek, Belgium.Hellings, N, Hasselt Univ, Biomed Onderzoeksinst, Agoralaan Bldg A, B-3590 Diepenbeek, Belgium.niels.hellings@uhasselt.be
URI: http://hdl.handle.net/1942/1990
DOI: 10.1016/j.jneuroim.2006.04.012
ISI #: 000240261100022
ISSN: 0165-5728
Category: A1
Type: Journal Contribution
Validation: ecoom, 2007
Appears in Collections: Research publications

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