Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19890

Title: Monitoring of the Enzymatically Catalyzed Degradation of Biodegradable Polymers by Means of Capacitive Field-Effect Sensors
Authors: Schusser, Sebastian
Krischer, Maximilian
Bäcker, Matthias
Poghossian, Arshak
Wagner, Patrick
Schöning, Michael J.
Issue Date: 2015
Citation: ANALYTICAL CHEMISTRY, 87 (13), p. 6607-6613
Abstract: Designing novel or optimizing existing biodegradable polymers for biomedical applications requires numerous tests on the effect of substances on the degradation process. In the present work, polymer-modified electrolyte insulator semiconductor (PMEIS) sensors have been applied for monitoring an enzymatically catalyzed degradation of polymers for the first time. The thin films of biodegradable polymer poly(D,L-lactic acid) and enzyme lipase were used as a model system. During degradation, the sensors were read-out by means of impedance spectroscopy. In order to interpret the data obtained from impedance measurements, an electrical equivalent circuit model was developed. In addition, morphological investigations of the polymer surface have been performed by means of in situ atomic force microscopy. The sensor signal change, which reflects the progress of degradation, indicates an accelerated degradation in the presence of the enzyme compared to hydrolysis in neutral pH buffer media. The degradation rate increases with increasing enzyme concentration. The obtained results demonstrate the potential of PMEIS sensors as a very promising tool for in situ and real-time monitoring of degradation of polymers.
Notes: [Schusser, Sebastian; Krischer, Maximilian; Baecker, Matthias; Poghossian, Arshak; Schoening, Michael J.] FH Aachen, INB, Julich, Germany. [Schusser, Sebastian; Baecker, Matthias; Poghossian, Arshak; Schoening, Michael J.] Forschungszentrum Julich, Peter Grunberg Inst PGI 8, D-52425 Julich, Germany. [Wagner, Patrick] Katholieke Univ Leuven, Dept Phys & Astron, Leuven, Belgium. [Wagner, Patrick] Hasselt Univ, Inst Mat Res IMO, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/19890
DOI: 10.1021/acs.analchem.5b00617
ISI #: 000357839700030
ISSN: 0003-2700
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
N/A2.63 MBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.