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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19888

Title: Fetal growth and maternal exposure to particulate air pollution - More marked effects at lower exposure and modification by gestational duration
Authors: Winckelmans, Ellen
Cox, Bianca
Martens, Evelyne
Fierens, Frans
Nemery, Benoit
Nawrot, Tim
Issue Date: 2015
Citation: ENVIRONMENTAL RESEARCH, 140, p. 611-618
Abstract: While there is growing evidence that air pollution reduces fetal growth, results are inconclusive with respect to the gestational window of effect. We investigated maternal exposure to particulate matter (PM10) in association with birth weight and fetus growth with a focus on the shape of the association and gestational age at birth as a potential effect modifier. The study population consisted of 525,635 singleton live births in Flanders (Belgium) between 1999 and 2009. PM10 exposure at maternal residence was averaged over various time windows. We used robust linear and logistic regression to estimate the effect of PM10 on birth weight and small for gestational age (SGA). Segmented regression models were applied for non-linear associations. Among moderately preterm (32-36 weeks) and term ( > 36 weeks) births, we found significant lower birth weight for all studied time windows. The estimated reduction in birth weight for a 10 mu g/m(3) increase in average PM10 during pregnancy was 39.0 g (95% confidence interval [CI]: 26.4, 51.5 g) for moderately preterm births and 24.0 g (95% Cl: 20.9, 27.2 g) for term births. The corresponding odds ratios for SGA were 1.19 (95% CI: 1.07, 1.32) and 1.09 (95% Cl: 1.06, 1.12) respectively. Segmented regression models showed stronger effects of PM10 on fetal growth at lower concentrations. Maternal PM10 exposure was significantly associated with a reduction in fetal growth among term and moderately preterm births, with a tendency of stronger effects for the latter and a flattening out of the slope at higher PM10 concentrations. (C) 2015 Published by Elsevier Inc.
Notes: [Winckelmans, Ellen; Cox, Bianca; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. [Martens, Evelyne] Study Ctr Perinatal Epidemiol, B-1060 Brussels, Belgium. [Fierens, Frans] Belgian Interreg Environm Agcy, B-1210 Brussels, Belgium. [Nemery, Benoit; Nawrot, Tim S.] Univ Leuven, KU Leuven, Dept Publ Hlth & Primary Care Environm & Hlth, B-3000 Leuven, Belgium.
URI: http://hdl.handle.net/1942/19888
DOI: 10.1016/j.envres.2015.05.015
ISI #: 000357904100070
ISSN: 0013-9351
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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