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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19851

Title: Belgian experience with triple therapy with boceprevir and telaprevir in genotype 1 infected patients who inject drugs
Authors: Arain, Amber
Bourgeois, S.
de Galocsy, C.
Henrion, J.
Deltenre, P.
d'Heygere, F.
George, C.
Bastens, B.
Van Overbeke, L.
Verrando, R.
Bruckers, Liesbeth
Mathei, Catharina
Buntinx, F.
Van Vlierberghe, H.
Francque, S.
Laleman, W.
Moreno, C.
Janssens, F.
Nevens, F.
Robaeys, Geert
Issue Date: 2016
Publisher: WILEY-BLACKWELL
Citation: JOURNAL OF MEDICAL VIROLOGY, 88 (1), p. 94-99
Abstract: No data have been reported yet on treatment outcome in persons who inject drugs (PWID) infected with hepatitis C virus treated with boceprevir or telaprevir in combination with peginterferon (Peg IFN) and ribavirin (RBV). Additionally, there are concerns about the safety of boceprevir and telaprevir in some subgroups of patients with hepatitis C (HCV). In a cohort of HCV patients infected with genotype 1 in Belgium, treatment outcome of patients infected due to IV drug use was analyzed and compared with patients who have no history of substance use. The study population consisted of 179 patients: 78 PWID and 101 controls treated with boceprevir (n=79) or telaprevir (n=100) additional to Peg IFN and RBV; 53 (30%) had advanced disease (F3, F4) and 79 (44%) had an antiviral therapy previously. There were no significant differences in the baseline characteristics between both groups, except that PWID patients were more frequently infected with genotype 1a (67% vs 21%), were younger and were predominantly male. Psychiatric complaints during follow-up occurred more frequently in the PWID patients: 24% versus 11% (P=.02). Treatment failure for other reasons than absence of viral response was 70% and 64% in PWID and non-PWID respectively. The sustained viral response (SVR) rates were similar in both groups (71% in PWID vs 72% in non-PWID); with a non-inferiority test with -5% margin there is a difference of -1% (95% CI [-15%, 13%]) and P=0.30. There are no reasons to exclude PWID from treatment with boceprevir, telaprevir and novel antiviral therapies. J. Med. Virol. 88:94-99, 2016. (c) 2015 Wiley Periodicals, Inc.
Notes: [Arain, A.; Robaeys, G.] Ziekenhuis Oost Limburg, Dept Gastroenterol & Hepatol, B-3600 Genk, Belgium. [Arain, A.; Robaeys, G.] Hasselt Univ, Fac Med & Life Sci, B-3500 Hasselt, Belgium. [Bourgeois, S.] ZNA Stuyvenberg, Dept Gastroenterol & Hepatol, Antwerp, Belgium. [de Galocsy, C.] Hop Iris Sud Bracops, Dept Gastroenterol & Hepatol, Brussels, Belgium. [Henrion, J.; Deltenre, P.] Hop Jolimont, Dept Gastroenterol & Hepatol, Haine St Paul, Belgium. [Deltenre, P.] CHU Vaudois, Div Gastroenterol & Hepatol, CH-1011 Lausanne, Switzerland. [d'Heygere, F.; George, C.] AZ Groeninge, Dept Gastroenterol & Hepatol, Kortrijk, Belgium. [Bastens, B.] Clin Esperance, Clin St Joseph, Dept Gastroenterol & Hepatol, Liege, Belgium. [Van Overbeke, L.] AZ St Maarten, Dept Gastroenterol & Hepatol, Mechelen, Belgium. [Verrando, R.] Med Sociaal Opvangctr Limburg, Genk, Belgium. [Bruckers, L.] Hasselt Univ, Ctr Stat CenStat, Hasselt, Belgium. [Mathei, C.] Free Clin, Antwerp, Belgium. [Mathei, C.] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Leuven, Belgium. [Buntinx, F.] Katholieke Univ Leuven, Dept Gen Practice, Leuven, Belgium. [Buntinx, F.] Maastricht Univ, NL-6200 MD Maastricht, Netherlands. [Van Vlierberghe, H.] Ghent Univ Hosp, Dept Gastroenterol & Hepatol, Ghent, Belgium. [Francque, S.] UZ Antwerp, Dept Gastroenterol & Hepatol, Antwerp, Belgium. [Laleman, W.; Nevens, F.; Robaeys, G.] Univ Hosp KULeuven, Dept Hepatol, Leuven, Belgium. [Moreno, C.] Univ Libre Bruxelles, CUB Hop Erasme, Dept Gastroenterol Hepatopancreatol & Digest Onco, Brussels, Belgium. [Janssens, F.] Jessa Hosp, Dept Gastroenterol & Hepatol, Hasselt, Belgium.
URI: http://hdl.handle.net/1942/19851
DOI: 10.1002/jmv.24308
ISI #: 000363894900013
ISSN: 0146-6615
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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