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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19847

Title: Evaluation of theophylline imprinted polypyrrole film
Authors: Baleviciute, Ieva
Ratautaite, Vilma
Ramanaviciene, Almira
Balevicius, Zigmas
Broeders, Jeroen
Croux, Dieter
McDonald, Matthew
Vahidpour, Farnoosh
Thoelen, Ronald
De Ceuninck, Ward
Haenen, Ken
Nesladek, Milos
Reza, Alfonsas
Ramanavicius, Arunas
Issue Date: 2015
Citation: SYNTHETIC METALS, 209, p. 206-211
Abstract: In this study some affinity and dielectric properties of molecularly imprinted (MIP) conducting polymer-polypyrrole (Ppy) based thin films were evaluated. Films of polypyrrole molecularly imprinted with theophylline (MIP-Ppy) and non-imprinted polypyrrole (NIP-Ppy) were formed on boron doped silicon (Si) substrates in order to evaluate the efficiency of Ppy to bind theophylline. The substrates were modified with boron-doped oxygen terminated nanocrystalline diamond (B:NCD:O) The dielectric properties of B:NCD:O/Ppy-based multi-layered structures were analyzed using spectroscopic ellipsometry and spectrophotometric techniques. Electrochemical impedance spectroscopy was applied for the investigation of kinetics of theophylline interaction with MIP-Ppy and NIP-Ppy. The sensitivity of molecularly imprinted and non-imprinted polymer films was analyzed by injection of different theophylline concentrations. Assuming that Ppy film electrical capacitance change is a result of Ppy dielectric constant change induced by absorbed theophylline molecules, the electrical capacitance change (Delta C) kinetics at different concentrations of theophylline was analyzed using first pseudo order kinetic equation. The dissociation equilibrium constant K-D of MIP-Ppy/theophylline complex at room temperature was calculated as 1.7 x 10(-8) M, and Gibbs free energy change (Delta G) of MIP-Ppy/theophylline complex formation was calculated as -43.5 kJ/mol. It was concluded that molecularly imprinted polypyrrole thin film could be used for the detection of theophylline. (c) 2015 Elsevier B.V. All rights reserved.
Notes: [Baleviciute, Ieva; Ratautaite, Vilma; Ramanavicius, Arunas] Vilnius State Univ, Fac Chem, Dept Phys Chem, Vilnius, Lithuania. [Balevicius, Zigmas] State Res Inst, Ctr Phys Sci & Technol, Lab BionanoTechnol, Vilnius, Lithuania. [Ramanaviciene, Almira] Vilnius State Univ, Fac Chem, NanoTechnas Ctr Nanotechnol & Mat Sci, Vilnius, Lithuania. [Broeders, Jeroen; Croux, Dieter; McDonald, Matthew; Vahidpour, Farnoosh; Thoelen, Ronald; De Ceuninck, Ward; Haenen, Ken] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. [Thoelen, Ronald; Nesladek, Milos] Res Inst IMEC Vzw, Res Ctr IMOMEC, B-3590 Diepenbeek, Belgium. [De Ceuninck, Ward] Xios Univ Coll, B-3590 Diepenbeek, Belgium. [Reza, Alfonsas] State Res Inst, Dept Optoelect, Ctr Phys Sci & Technol, Vilnius, Lithuania.
URI: http://hdl.handle.net/1942/19847
DOI: 10.1016/j.synthmet.2015.07.021
ISI #: 000364245900031
ISSN: 0379-6779
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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