Document Server@UHasselt >
Research publications >
Please use this identifier to cite or link to this item:
|Title: ||Endocrine actions of pesticides measured in the Flemish environment and health studies (FLEHS I and II)|
|Authors: ||Croes, Kristof|
Den Hond, E.
Van Larebeke, N.
|Issue Date: ||2015|
|Publisher: ||SPRINGER HEIDELBERG|
|Citation: ||ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 22 (19), p. 14589-14599|
|Abstract: ||Within the Flemish Environment and Health studies (FLEHS I, 2002-2006, and FLEHS II, 2007-2012), pesticide exposure, hormone levels and degree of sexual maturation were measured in 14-15-year-old adolescents residing in Flanders (Belgium). In FLEHS II, geometric mean concentrations (with 95 % confidence interval (CI)) of 307 (277-341) and 36.5 ng L-1 (34.0-39.2) were found for p,p'-dichlorophenyldichloroethylene (p,p'-DDE) and hexachlorobenzene (HCB). These values were respectively 26 and 60 % lower than levels in FLEHS I, 5 years earlier. Metabolites of organophosphorus pesticides (OPPs) and of para-dichlorobenzene were measured for the first time in FLEHS II, yielding concentrations of 11.4, 3.27 and 1.57 mu g L-1 for the sum of dimethyl- and diethyl phosphate metabolites and 2,5-dichlorophenol (2,5-DCP), respectively. Data on internal exposure of HCB showed a positive correlation with sexual maturation, testosterone and the aromatase index for boys and with free thyroxine (fT4) and thyroid stimulating hormone (TSH) (both boys and girls). For both p,p'-DDE and HCB, a negative association with sexual development in girls was found. The OPP metabolites were negatively associated with sex hormone levels in the blood of boys and with sexual maturation (both boys and girls). The pesticide metabolite 2,5-DCP was negatively correlated with free T4, while a positive association with TSH was reported (boys and girls). These results show that even exposure to relatively low concentrations of pesticides can have significant influences on hormone levels and the degree of sexual maturation in 14-15-year-old adolescents.|
|Notes: ||[Croes, K.; Van Larebeke, N.; Baeyens, W.] Vrije Univ Brussel, Dept Analyt Environm & Geochem AMGC, B-1050 Brussels, Belgium. [Den Hond, E.; Govarts, E.; Schoeters, G.] Flemish Inst Technol Res VITO, Environm Risk & Hlth, B-2400 Mol, Belgium. [Bruckers, L.] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, B-3590 Diepenbeek, Belgium. [Schoeters, G.] Univ Antwerp, Dept Biomed Sci, B-2610 Antwerp, Belgium. [Covaci, A.] Univ Antwerp, Toxicol Ctr, B-2020 Antwerp, Belgium. [Loots, I.; Morrens, B.] Univ Antwerp, Polit & Social Sci, B-2020 Antwerp, Belgium. [Nelen, V.] Prov Inst Hyg, Antwerp, Belgium. [Sioen, I.] Univ Ghent, Dept Publ Hlth, B-9000 Ghent, Belgium.|
|ISI #: ||000362329300021|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2016|
|Appears in Collections: ||Research publications|
Files in This Item:
|N/A||228.96 kB||Adobe PDF|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.