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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19818

Title: Dental Stem Cells in Pulp Regeneration: Near Future or Long Road Ahead?
Authors: Hilkens, Petra
Meschi, Nastaran
Lambrechts, Paul
Bronckaers, Annelies
Lambrichts, Ivo
Issue Date: 2015
Publisher: MARY ANN LIEBERT, INC
Citation: STEM CELLS AND DEVELOPMENT, 24 (14), p. 1610-1622
Abstract: Although regenerative endodontic procedures have yielded an impressive body of favorable outcomes, the treatment of necrotic immature permanent teeth in particular remains to be a challenge. Recent advances in dental stem cell (DSC) research have gained increasing insight in their regenerative potential and prospective use in the formation of viable dental tissues. Numerous studies have already reported successful dental pulp regeneration following application of dental pulp stem cells, stem cells from the apical papilla, or dental follicle precursor cells in different in vivo models. Next to responsive cells, dental tissue engineering also requires the support of an appropriate scaffold material, ranging from naturally occurring polymers to treated dentin matrix components. However, the routine use and banking of DSCs still holds some major challenges, such as culture-associated differences, patient-related variability, and the effects of culture medium additives. Only in-depth evaluation of these problems and the implementation of standardized models and protocols will effectively lead to better alternatives for patients who no longer benefit from current treatment protocols.
Notes: Address correspondence to: Petra Hilkens Laboratory of Morphology Biomedical Research Institute (BIOMED) Hasselt University Agoralaan, Building C Diepenbeek 3590 Belgium E-mail: petra.hilkens@uhasselt.be
URI: http://hdl.handle.net/1942/19818
DOI: 10.1089/scd.2014.0510
ISI #: 000362083600002
ISSN: 1547-3287
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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