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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19810

Title: Glial regulation of the blood-brain barrier in health and disease
Authors: Broux, Bieke
Gowing, Elizabeth
Prat, Alexandre
Issue Date: 2015
Citation: SEMINARS IN IMMUNOPATHOLOGY, 37 (6), p. 577-590
Abstract: The brain is the organ with the highest metabolic demand in the body. Therefore, it needs specialized vasculature to provide it with the necessary oxygen and nutrients, while protecting it against pathogens and toxins. The blood-brain barrier (BBB) is very tightly regulated by specialized endothelial cells, two basement membranes, and astrocytic endfeet. The proximity of astrocytes to the vessel makes them perfect candidates to influence the function of the BBB. Moreover, other glial cells are also known to contribute to either BBB quiescence or breakdown. In this review, we summarize the knowledge on glial regulation of the BBB during development, in homeostatic conditions in the adult, and during neuroinflammatory responses.
Notes: [Broux, Bieke; Gowing, Elizabeth; Prat, Alexandre] Univ Montreal CRCHUM, Ctr Hosp, Ctr Rech, Neuroimmunol Unit, Montreal, PQ H2X 0A9, Canada. [Broux, Bieke; Gowing, Elizabeth; Prat, Alexandre] Univ Montreal, Fac Med, Dept Neurosci, Montreal, PQ H3C 3J7, Canada. [Broux, Bieke] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Broux, Bieke] Transnatl Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/19810
DOI: 10.1007/s00281-015-0516-2
ISI #: 000363271700002
ISSN: 1863-2297
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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