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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19808

Title: Recommendations for the management of hepatitis C virus infection among people who inject drugs
Authors: Grebely, Jason
Robaeys, Geert
Bruggmann, Philip
Aghemo, Alessio
Backmund, Markus
Bruneau, Julie
Byrne, Jude
Dalgard, Olav
Feld, Jordan J.
Hellard, Margaret
Hickman, Matthew
Kautz, Achim
Litwin, Alain
Lloyd, Andrew R.
Mauss, Stefan
Prins, Maria
Swan, Tracy
Schaefer, Martin
Taylor, Lynn E.
Dore, Gregory J.
Issue Date: 2015
Publisher: ELSEVIER SCIENCE BV
Citation: INTERNATIONAL JOURNAL OF DRUG POLICY, 26 (10), p. 1028-1038
Abstract: In high income countries, the majority of new and existing hepatitis C virus (HCV) infections occur among people who inject drugs (PWID). In many low and middle income countries large HCV epidemics have also emerged among PWID populations. The burden of HCV-related liver disease among PWID is increasing, but treatment uptake remains extremely low. There are a number of barriers to care which should be considered and systematically addressed, but should not exclude PWID from HCV treatment. The rapid development of interferon-free direct-acting antiviral (DAA) therapy for HCV infection has brought considerable optimism to the HCV sector, with the realistic hope that therapeutic intervention will soon provide near optimal efficacy with well-tolerated, short duration, all oral regimens. Further, it has been clearly demonstrated that HCV treatment is safe and effective across a broad range of multidisciplinary healthcare settings. Given the burden of HCV-related disease among PWID, strategies to enhance HCV assessment and treatment in this group are urgently needed. These recommendations demonstrate that treatment among PWID is feasible and provide a framework for HCV assessment and care. Further research is needed to evaluate strategies to enhance testing, linkage to care, treatment, adherence, viral cure, and prevent HCV reinfection among PWID, particularly as new interferon-free DAA treatments for HCV infection become available. (C) 2015 Elsevier B.V. All rights reserved.
Notes: [Grebely, Jason; Dore, Gregory J.] UNSW Australia, Kirby Inst, Sydney, NSW, Australia. [Robaeys, Geert] Ziekenhuis Oost Limburg, Dept Gastroenterol & Hepatol, Genk, Belgium. [Robaeys, Geert] UZ Leuven, Dept Hepatol, Leuven, Belgium. [Robaeys, Geert] Hasselt Univ, Limburg Clin Res Program, Fac Med & Life Sci, Hasselt, Belgium. [Bruggmann, Philip] Arud Ctr Addict Med, Zurich, Switzerland. [Aghemo, Alessio] Univ Milan, AM Migliavacca Ctr Liver Dis, Div Gastroenterol & Hepatol, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy. [Backmund, Markus] Univ Munich, Munich, Germany. [Backmund, Markus] Praxiszentrum Tal Munich, Munich, Germany. [Bruneau, Julie] Univ Montreal, CRCHUM, Montreal, PQ, Canada. [Byrne, Jude] Int Network People who Use Drugs, Canberra, ACT, Australia. [Dalgard, Olav] Akershus Univ Hosp, Dept Infect Dis, Lorenskog, Norway. [Feld, Jordan J.] Univ Toronto, Toronto, ON, Canada. [Hellard, Margaret] Burnet Inst, Melbourne, Australia. [Hellard, Margaret] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia. [Hickman, Matthew] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England. [Kautz, Achim] European Liver Patients Assoc, Cologne, Germany. [Litwin, Alain] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Div Gen Internal Med, Bronx, NY 10467 USA. [Litwin, Alain] Montefiore Med Ctr, Bronx, NY 10467 USA. [Lloyd, Andrew R.] UNSW Australia, Sch Med Sci, Inflammat & Infect Res Ctr, Sydney, NSW, Australia. [Mauss, Stefan] Ctr HIV & Hepatogastroenterol, Dusseldorf, Germany. [Prins, Maria] Publ Hlth Serv Amsterdam, Dept Res, Cluster Infect Dis, Amsterdam, Netherlands. [Prins, Maria] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, CINIMA, NL-1105 AZ Amsterdam, Netherlands. [Swan, Tracy] Treatment Act Grp, New York, NY USA. [Schaefer, Martin] Kliniken Essen Mitte, Dept Psychiat Psychotherapy & Addict Med, Essen, Germany. [Schaefer, Martin] Charite, Dept Psychiat & Psychotherapy CCM, D-13353 Berlin, Germany. [Taylor, Lynn E.] Brown Univ, Dept Med, Providence, RI 02912 USA.
URI: http://hdl.handle.net/1942/19808
DOI: 10.1016/j.drugpo.2015.07.005
ISI #: 000362858500017
ISSN: 0955-3959
Category: A2
Type: Journal Contribution
Appears in Collections: Research publications

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