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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19765

Title: Soluble CD146, a new endothelial biomarker of acutely decompensated heart failure
Authors: Gayat, Etienne
Caillard, Anais
Laribi, Said
Mueller, Christian
Sadoune, Malha
Seronde, Marie-France
Maisel, Alan
Bartunek, Jozef
Vanderheyden, Marc
Desutter, Johan
Dendale, Paul
Thomas, Gregoire
Tavares, Miguel
Cohen-Solal, Alain
Samuel, Jane-Lise
Mebazaa, Alexandre
Issue Date: 2015
Abstract: Background: The present study involved both human cohorts and animal experiments to explore the performance of soluble CD146 (sCD146), a marker of endothelial function, as a diagnostic marker of acutely decompensated heart failure (ADHF), to determine the influence of patients' characteristics on that performance and to explore the potential application of CD146 in the pathophysiology of ADHF. Methods and results: NT-proBNP and sCD146 were measured in three hundred ninety-one patients admitted to the emergency department for acute dyspnea. ROC curve analysis demonstrated that AUCs for ADHF diagnosis in dyspneic patients were 0.86 (95% CI: 0.82-0.90) for sCD146 and 0.90 (95% CI: 0.86-0.92) for NT-proBNP. Subgroup analyses demonstrated that adding sCD146 to NT-proBNP improved the diagnostic performance for patients lying in the gray zone of NT-proBNP (p = 0.02) and could be especially useful for ruling-out ADHF. An experimental model of ADHF in rats using thoracic aortic constriction suggests that CD146 is expressed in the intima of large arteries and associated with both left ventricular function and organ congestion. Conclusions: sCD146, a marker of endothelial function, seems to be as powerful as NT-proBNP is used to detect the cardiac origin of an acute dyspnea. The combination of sCD146 and NT-proBNP may have better performance than NT-proBNP used alone in particular for patients underlying in the "gray" zone and could therefore be an improved option for ruling-out ADHF. Both experimental and human data suggest that CD146 is related to systolic left ventricular function and to organ congestion. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Notes: [Gayat, Etienne; Caillard, Anais; Laribi, Said; Samuel, Jane-Lise; Mebazaa, Alexandre] St Louis Lariboisiere Univ Hosp, AP HP, Dept Anesthesiol & Crit Care Med, Paris, France. [Gayat, Etienne; Caillard, Anais; Laribi, Said; Sadoune, Malha; Seronde, Marie-France; Cohen-Solal, Alain; Samuel, Jane-Lise; Mebazaa, Alexandre] INSERM, UMR S 942, Paris, France. [Gayat, Etienne; Caillard, Anais; Sadoune, Malha; Cohen-Solal, Alain; Mebazaa, Alexandre] Univ Paris Diderot, Paris, France. [Laribi, Said] St Louis Lariboisiere Univ Hosp, AP HP, Emergency Dept, Paris, France. [Mueller, Christian] Univ Basel Hosp, CH-4031 Basel, Switzerland. [Seronde, Marie-France] Univ Hosp Jean Minjoz, Dept Cardiol EA3920, Besancon, France. [Maisel, Alan] Univ Calif San Diego, San Diego VA Med Ctr, San Diego, CA 92103 USA. [Bartunek, Jozef; Vanderheyden, Marc] Onze Lieve Vrouw Hosp, Ctr Cardiovasc, B-9300 Aalst, Belgium. [Desutter, Johan] Univ Ghent, AZ Maria Middelares Hosp Gent, Dept Cardiol, Ghent, Belgium. [Dendale, Paul] Hasselt Univ, Heart Ctr Hasselt, Hasselt, Belgium. [Thomas, Gregoire] SQU4RE, Lokeren, Belgium. [Tavares, Miguel] Hosp Geral Santo Antonio, Oporto, Portugal. [Cohen-Solal, Alain] St Louis Lariboisiere Univ Hosp, AP HP, Dept Cardiol, St Louis, France.
URI: http://hdl.handle.net/1942/19765
DOI: 10.1016/j.ijcard.2015.07.039
ISI #: 000361150100052
ISSN: 0167-5273
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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