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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19752

Title: Human exposure to endocrine, disrupting chemicals and fertility: A case-control study in male subfertility patients
Authors: Den Hond, Elly
Tournaye, Herman
De Sutter, Petra
Ombelet, Willem
Baeyens, Willy
Covaci, Adrian
Cox, Bianca
Nawrot, Tim S.
Van Larebeke, Nik
D'Hooghe, Thomas
Issue Date: 2015
Citation: ENVIRONMENT INTERNATIONAL, 84, p. 154-160
Abstract: Background: Dioxins, PCBs, chlorinated pesticides, brominated flame retardants, bisphenol A, triclosan, perfluorinated compounds and phthalates are known as endocrine disrupting chemicals (EDCs). Objectives: The aim of our study was to investigate whether higher exposure to EDCs is associated with increased subfertility in men. Methods: We measured biomarkers of exposure in 163 men, recruited through four fertility clinics. According to WHO guidelines, we used a total motility count (TMC) of 20 million as cut-off value. We assigned patients to the case group when two semen samples collected at least one week apart had a TMC < 20 and to the control group when both samples had a TMC >= 20. To estimate the risk of subfertility and alteration-in sex hormone concentrations we used multivariable-adjusted analysis, using logistic and linear regressions, respectively. Results: For an IQR increase in serum oxychlordane, the odds ratio for subfertility was 1.98 (95% CI: 1.07; 3.69). Furthermore, men with serum levels of BDE209 above the quantification limit had an odds of 7.22 (1.03; 50.6) for subfertility compared with those having values below the LOQ. Urinary levels of phthalates and triclosan were negatively associated with inhibin B and positively with LH. Urinary bisphenol A correlated negatively with testosterone levels. Conclusions: Our study in men showed that internal body concentrations of endocrine disrupting chemicals are associated with an increased risk of subfertility together with alterations in hormone levels. The results emphasize the importance to reduce chemicals in the environment in order to safeguard male fertility. (C) 2015 Elsevier Ltd. All rights reserved.
Notes: [Den Hond, Elly] Flemish Inst Technol Res VITO, Environm Risk & Hlth Unit, Mol, Belgium. [Den Hond, Elly] Sci Inst Publ Hlth, Directorate Publ Hlth & Surveillance, Brussels, Belgium. [Tournaye, Herman] Free Univ Brussels VUB, Univ Hosp Brussels, Ctr Reprod Med, Brussels, Belgium. [De Sutter, Petra] Univ Ghent, Univ Hosp Ghent, Dept Reprod Med, B-9000 Ghent, Belgium. [Ombelet, Willem] ZOL Hosp, Genk Inst Fertil Technol, Dept Obstet & Gynaecol, Genk, Belgium. [Ombelet, Willem] Hasselt Univ, Fac Med & Life Sci, Diepenbeek, Belgium. [Baeyens, Willy; Van Larebeke, Nik] Vrije Univ Brussel, Dept Analyt Environm & Geochem, Brussels, Belgium. [Covaci, Adrian] Univ Antwerp, Dept Pharmaceut Sci, Toxicol Ctr, Antwerp, Belgium. [Cox, Bianca; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Nawrot, Tim S.] Leuven Univ, Dept Publ Hlth & Primary Care, Leuven, Belgium. [Van Larebeke, Nik] Univ Ghent, Study Ctr Carcinogenesis, B-9000 Ghent, Belgium. [Van Larebeke, Nik] Univ Ghent, Primary Prevent Canc, B-9000 Ghent, Belgium. [D'Hooghe, Thomas] Katholieke Univ Leuven, Univ Hosp Gasthuisberg, Div Reprod Med, Leuven, Belgium.
URI: http://hdl.handle.net/1942/19752
DOI: 10.1016/j.envint.2015.07.017
ISI #: 000362143600016
ISSN: 0160-4120
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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