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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19687

Title: Prognostic value of variables derived from the six-minute walk test in patients with COPD: Results from the ECLIPSE study
Authors: Andrianopoulos, Vasileios
Wouters, Emiel F. M.
Pinto-Plata, Victor M.
Vanfleteren, Lowie E. G. W.
Bakke, Per S.
Franssen, Frits M. E.
Agusti, Alvar
MacNee, William
Rennard, Stephen I.
Tal-Singer, Ruth
Vogiatzis, Ioannis
Vestbo, Jorgen
Celli, Bartolome R.
Spruit, Martijn A.
Issue Date: 2015
Citation: RESPIRATORY MEDICINE, 109 (9), p. 1138-1146
Abstract: In addition to the six-min walk distance (6 MWD), other six-min walk test (6 MWT) derived variables, such as mean walk-speed (6MWSpeed), 6-min walk-work (6 MWW), distance-saturation product (DSP), exercise-induced oxygen desaturation (EID), and unintended stops may be useful for the prediction of mortality and hospitalization in patients with chronic obstructive pulmonary disease (COPD). We studied the association between 6 MWT-derived variables and mortality as well as hospitalization in COPD patients and compared it with the BODE index. A three-year prospective study (ECLIPSE) to evaluate the prognostic value of 6 MWT-derived variables in 2010 COPD patients. Cox's proportional-hazard regressions were performed to estimate 3-year mortality and hospitalization. During the follow-up, 193 subjects died and 622 were hospitalized. An adjusted Cox's regression model of hazard ratio [HR] for impaired 6 MWT-derived variables was significant referring to: mortality (6 MWD <= 334 m [2.30], 6MWSpeed <= 0.9 m/ sec [2.15], 6 MWW <= 20000 m kg [2.17], DSP <= 290 m% [2.70], EID <= 88% [1.75], unintended stops [1.99]; and hospitalization (6 MWW <= 27000 m kg [1.23], EID <= 88% [1.25], BODE index >= 3 points [1.40]; all p <= 0.05). The 6 MWT-derived variables have an additional predictive value of mortality in patients with COPD. The 6 MWW, EID and the BODE index refine the prognosis of hospitalization. (C) 2015 Elsevier Ltd. All rights reserved.
Notes: [Andrianopoulos, Vasileios; Wouters, Emiel F. M.; Vanfleteren, Lowie E. G. W.; Franssen, Frits M. E.; Spruit, Martijn A.] CIRO, Ctr Expertise Chron Organ Failure, Dept Res & Educ, NL-6085 Horn, Netherlands. [Wouters, Emiel F. M.] Maastricht Univ Med Ctr, Dept Resp Med, Maastricht, Netherlands. [Pinto-Plata, Victor M.] Univ Liverpool, Sch Clin Sci, Dept Resp Med, Liverpool L69 3BX, Merseyside, England. [Bakke, Per S.] Univ Bergen, Dept Clin Sci, Bergen, Norway. [Agusti, Alvar] Univ Barcelona, Thorax Inst, Hosp Clin, IDIBAPS,CIBERES, Barcelona, Spain. [MacNee, William] Univ Edinburgh, Queens Med Res Inst, MRC, Ctr Inflammat Res, Edinburgh, Midlothian, Scotland. [Rennard, Stephen I.] Univ Nebraska Med Ctr, Pulm & Crit Care Med, Omaha, NE USA. [Tal-Singer, Ruth] King Prussia, GSK Res & Dev, King Of Prussia, PA USA. [Vogiatzis, Ioannis] Univ Athens, Dept Phys Educ & Sport Sci, Athens, Greece. [Vestbo, Jorgen] Odense Univ Hosp, Dept Resp Med, DK-5000 Odense, Denmark. [Vestbo, Jorgen] Univ Manchester, Manchester Acad Hlth Sci Ctr, Resp & Allergy Res Grp, Manchester, Lancs, England. [Celli, Bartolome R.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. [Spruit, Martijn A.] Hasselt Univ, BIOMED Biomed Res Inst, Fac Med & Life Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/19687
DOI: 10.1016/j.rmed.2015.06.013
ISI #: 000360925800007
ISSN: 0954-6111
Category: A1
Type: Proceedings Paper
Validation: ecoom, 2016
Appears in Collections: Research publications

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