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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19162

Title: Association of total cancer and lung cancer with environmental exposure to cadmium: the meta-analytical evidence
Authors: Nawrot, Tim
Martens, Dries
Hara, Azusa
Plusquin, Michelle
Vangronsveld, Jaco
Roels, Harry
Staessen, Jan A.
Issue Date: 2015
Publisher: SPRINGER
Citation: CANCER CAUSES & CONTROL, 26 (9), p. 1281-1288
Abstract: Recent studies are indicative of substantial progress in understanding the dose-response relation between the incidence of total and lung cancer and environmental cadmium exposure. We conducted a meta-analysis of population studies that examined the risk of cancer in relation to lifetime exposure to cadmium. We searched MEDLINE, Web of Science, and relevant reviews until August 2014 for studies on the association between cancer risk and cadmium exposure. Eligible studies had to include an estimate of lifetime exposure to cadmium as reflected by the urinary cadmium concentration and adjustment of the cancer risk at least for age and smoking. We pooled relative risk across the studies estimates for cancer and lung cancer using variance-weighted random-effect models and expressed association sizes for a twofold increase in urinary cadmium, thereby respecting the continuous nature of the association. The meta-analysis included 20,459 participants from three prospective population studies. The average urinary cadmium concentration across populations ranged from 0.25 to 0.93 A mu g/g creatinine. The relative risk of total cancer, associated with a doubling of the urinary cadmium concentration, ranged across the different studies from 1.18 to 1.31, and the pooled relative risk was 1.22 (95 % CI 1.13-1.31; p < 0.0001). For lung cancer, the relative risk ranged from 1.21 to 1.70 for a doubling of the urinary cadmium concentration, while the pooled relative risk amounted to 1.68 (1.47-1.92; p < 0.0001). Excluding one study at the time did not move the pooled estimates outside the confidence interval of the overall estimate for all studies combined. The epidemiological evidence of the last decade consistently identifies low-level environmental exposure to cadmium as a risk factor for total cancer and lung cancer.
Notes: [Nawrot, Tim S.; Martens, Dries S.; Plusquin, Michelle; Vangronsveld, Jaco; Roels, Harry A.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Nawrot, Tim S.] Leuven Univ, Dept Publ Hlth, Louvain, Belgium. [Hara, Azusa; Staessen, Jan A.] Univ Leuven, KU Leuven Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Studies Coordinating Ctr, Louvain, Belgium. [Staessen, Jan A.] Maastricht Univ, VitaK Res & Dev, Maastricht, Netherlands. [Roels, Harry A.] Catholic Univ Louvain, Louvain Ctr Toxicol & Appl Pharmacol, B-1200 Brussels, Belgium.
URI: http://hdl.handle.net/1942/19162
DOI: 10.1007/s10552-015-0621-5
ISI #: 000359941800006
ISSN: 0957-5243
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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