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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19131

Title: Humoral autoimmunity: A failure of regulatory T cells?
Authors: Dhaeze, Tessa
Stinissen, Piet
Liston, Adrian
Hellings, Niels
Issue Date: 2015
Citation: AUTOIMMUNITY REVIEWS, 14 (8), p. 735-741
Abstract: Regulatory T cells (Tregs) are essential in maintaining tolerance to self. Several lines of evidence indicate that Tregs are functionally impaired in a variety of autoimmune diseases, leading to inefficient regulation of autoimmune T cells. Recent findings also suggest that Tregs are essential in controlling autoreactive B cells. The recently identified follicular regulatory T cell subset (T-FR) is thought to regulate the production of autoantibodies in the germinal center (GC) response. Here we provide an update on the role of Tregs in controlling the GC response, and whether defective control over B cell tolerance contributes to autoimmunity. (C) 2015 Elsevier B.V. All rights reserved.
Notes: [Dhaeze, Tessa; Stinissen, Piet; Hellings, Niels] Hasselt Univ, Biomed Onderzoeksinst, Diepenbeek, Belgium. [Dhaeze, Tessa; Stinissen, Piet; Hellings, Niels] Transnatl Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. [Liston, Adrian] VIB, Autoimmune Genet Lab, Leuven, Belgium. [Liston, Adrian] Univ Leuven, Dept Microbiol & Immunol, Leuven, Belgium.
URI: http://hdl.handle.net/1942/19131
DOI: 10.1016/j.autrev.2015.04.006
ISI #: 000357243600011
ISSN: 1568-9972
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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