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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19130

Title: Transcranial direct current stimulation in Parkinson's disease: Neurophysiological mechanisms and behavioral effects.
Authors: Broeder, S.
Nackaerts, E.
Heremans, E.
Vervoort, G.
Meesen, R.L.J.
Verheyden, G.
Nieuwboer, A.
Issue Date: 2015
Citation: Neuroscience and biobehavioral reviews, 57, p. 105-117
Abstract: Recent research has highlighted the potential of transcranial direct current stimulation (tDCS) to complement rehabilitation effects in the elderly and in patients with neurological diseases, including Parkinson’s disease (PD). TDCS can modulate cortical excitability and enhance neurophysiological mechanisms that compensate for impaired learning in PD. The objective of this systematic review is to provide an overview of the effects of tDCS on neurophysiological and behavioral outcome measures in PD patients, both as a stand-alone and as an adjunctive therapy. We systematically reviewed the literature published throughout the last 10 years. Ten studies were included, most of which were sham controlled. Results confirmed that tDCS applied to the motor cortex had significant results on motor function and to a lesser extent on cognitive tests. However, the physiological mechanism underlying the long-term effects of tDCS on cortical excitability in the PD brain are still unclear and need to be clarified in order to apply this technique optimally to a wider population in the different disease stages and with different medication profiles.
Notes: Corresponding author. Tel.: +32 16 37 21 86. E-mail addresses: sanne.broeder@faber.kuleuven.be (S. Broeder), evelien.nackaerts@faber.kuleuven.be (E. Nackaerts), elke.heremans@faber.kuleuven.be (E. Heremans), griet.vervoort@faber.kuleuven.be (G. Vervoort), raf.meesen@uhasselt.be (R. Meesen), geert.verheyden@faber.kuleuven.be (G. Verheyden), alice.nieuwboer@faber.kuleuven.be (A. Nieuwboer).
URI: http://hdl.handle.net/1942/19130
Link to publication: http://www.ncbi.nlm.nih.gov/pubmed/26297812
DOI: 10.1016/j.neubiorev.2015.08.010
ISI #: 000364271200007
ISSN: 0149-7634
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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