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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/19092

Title: Synthesis of a multifunctional poly(p-phenylene ethynylene) scaffold with clickable azidecontaining side chains for (bio)sensor applications
Authors: BRAEKEN, Yasmine
LUTSEN, Laurence
MAES, Wouter
Issue Date: 2015
Citation: Polymer Chemistry, 6 (37), 6720-6731
Abstract: Poly(p-phenylene ethynylene) (PPE) copolymers with alternating alkoxy and azide-functionalized alkoxy side chains were efficiently synthesized via Sonogashira polymerization and the materials were fully characterized. Among the different synthetic protocols investigated, the best results were obtained when employing a pre-polymerization functionalization approach and upon implementing the azide-functionalized side chains on the diiodophenyl building block. End-capping of the conjugated polymer chains is shown to be essential for preventing side reactions. As a proof of principle, phenylacetylene is clicked in a nearly quantitative way on the polymer backbone. Furthermore, successful click-immobilization of randomly alkynylated protein A onto an azide-functionalized PPE film illustrates the potential use of these materials in a variety of (bio)sensor applications.
Notes: Maes, W (reprint author), Hasselt Univ, Inst Mat Res IMO IMOMEC, DSOS, Agoralaan 1,Bldg D, B-3590 Diepenbeek, Belgium wouter.maes@uhasselt.be
URI: http://hdl.handle.net/1942/19092
DOI: 10.1039/c5py00741k
ISI #: 000361207600015
ISSN: 1759-9954
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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