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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18998

Title: A systematic review on the innervation of peri-implant tissues with special emphasis on the influence of implant placement and loading protocols
Authors: HUANG, Yanru
Jacobs, Reinhilde
Van Dessel, Jeroen
Bornstein, Michael M.
POLITIS, Constantinus
Issue Date: 2015
Citation: CLINICAL ORAL IMPLANTS RESEARCH, 26 (7), p. 737-746
Abstract: ObjectivesTo systematically review the available literature on the influence of dental implant placement and loading protocols on peri-implant innervation. Material and methodsThe database MEDLINE, Cochrane, EMBASE, Web of Science, LILACS, OpenGrey and hand searching were used to identify the studies published up to July 2013, with a populations, exposures and outcomes (PEO) search strategy using MeSH keywords, focusing on the question: Is there, and if so, what is the effect of time between tooth extraction and implant placement or implant loading on neural fibre content in the peri-implant hard and soft tissues? ResultsOf 683 titles retrieved based on the standardized search strategy, only 10 articles fulfilled the inclusion criteria, five evaluating the innervation of peri-implant epithelium, five elucidating the sensory function in peri-implant bone. Three included studies were considered having a methodology of medium quality and the rest were at low quality. All those papers reported a sensory innervation around osseointegrated implants, either in the bone-implant interface or peri-implant epithelium, which expressed a particular innervation pattern. Compared to unloaded implants or extraction sites without implantation, a significant higher density of nerve fibres around loaded dental implants was confirmed. ConclusionsTo date, the published literature describes peri-implant innervation with a distinct pattern in hard and soft tissues. Implant loading seems to increase the density of nerve fibres in peri-implant tissues, with insufficient evidence to distinguish between the innervation patterns following immediate and delayed implant placement and loading protocols. Variability in study design and loading protocols across the literature and a high risk of bias in the studies included may contribute to this inconsistency, revealing the need for more uniformity in reporting, randomized controlled trials, longer observation periods and standardization of protocols.
Notes: [Huang, Yan; Jacobs, Reinhilde; Van Dessel, Jeroen; Bornstein, Michael M.; Politis, Constantinus] Univ Leuven, Dept Imaging & Pathol, OMFS IMPATH Res Grp, Fac Med,OIC, B-3000 Leuven, Belgium. [Huang, Yan; Jacobs, Reinhilde; Van Dessel, Jeroen; Bornstein, Michael M.; Politis, Constantinus] Univ Hosp Leuven, Oral & Maxillofacial Surg, Leuven, Belgium. [Huang, Yan] Sichuan Univ, West China Coll Stomatol, Oral Implant Ctr, Chengdu 610064, Peoples R China. [Bornstein, Michael M.] Univ Bern, Dept Oral Surg & Stomatol, Sect Dent Radiol & Stomatol, Bern, Switzerland. [Lambrichts, Ivo] Univ Hasselt, Lab Morphol, Fac Med, Biomed Res Inst, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/18998
DOI: 10.1111/clr.12344
ISI #: 000355958600001
ISSN: 0905-7161
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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