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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18954

Title: Physiological responses during downhill walking: A new exercise modality for subjects with chronic obstructive pulmonary disease?
Authors: Camillo, Carlos Augusto
BURTIN, Chris
Hornikx, Miek
Demeyer, Heleen
De Bent, Kristien
van Remoortel, Hans
Osadnik, Christian R.
JANSSENS, Wim
Troosters, Thierry
Issue Date: 2015
Publisher: SAGE PUBLICATIONS LTD
Citation: CHRONIC RESPIRATORY DISEASE, 12 (2), p. 155-164
Abstract: Skeletal muscle quadriceps low-frequency fatigue (LFF) during exercise promotes improvements in exercise capacity with exercise training. In healthy subjects, eccentric muscle work induced by downhill walking (DW) generates higher muscular stress, whilst metabolic cost is lower compared to level walking (LW). We investigated quadriceps LFF and metabolic cost of DW in patients with chronic obstructive pulmonary disease. Ten participants (67 +/- 7 years, FEV1 51 +/- 15% predicted) performed DW, DW carrying a load (DWL) of 10% body weight via vest and LW, in random order. Quadriceps potentiated twitch force (TWqpot) was assessed before and after each walk, and muscle damage was assessed before and 24 hours after each walk via serum creatine kinase (CK) levels. Ventilation (VE) and oxygen consumption (VO2) were measured via breath-by-breath analysis during each walk. DW and DWL resulted in a greater decrease in TWqpot (-30 +/- 14 N in DW, p < 0.05; and -22 +/- 16 N in DWL, p < 0.05) compared to LW (-3 +/- 21 N, p > 0.05). CK levels only increased 24 hours following DW and DWL (p < 0.05). DW and DWL showed lower VE and VO2 than LW (p < 0.05). DW is associated with enhanced quadriceps LFF and lower cardiorespiratory costs than LW. The addition of a chest load to DW does not seem to enhance these effects.
Notes: [Camillo, Carlos Augusto; Burtin, Chris; Hornikx, Miek; Demeyer, Heleen; van Remoortel, Hans; Osadnik, Christian R.; Troosters, Thierry] Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium. [Burtin, Chris] Hasselt Univ, Rehabil Res Ctr, Biomed Res Inst, Fac Med & Life Sci, Diepenbeek, Belgium. [De Bent, Kristien; Janssens, Wim; Troosters, Thierry] Univ Hosp Leuven, Resp Div & Rehabil, Leuven, Belgium. [Osadnik, Christian R.] Monash Univ, Dept Physiotherapy, Clayton, Vic 3800, Australia. [Osadnik, Christian R.] Inst Breathing & Sleep, Melbourne, Vic, Australia.Corresponding author: Thierry Troosters, Herestraat 49 bus 706, Onderwijs & Navorsing I, Labo Pneumologie, B-3000 Leuven, Belgium. Email: thierry.troosters@med.kuleuven.be
URI: http://hdl.handle.net/1942/18954
DOI: 10.1177/1479972315575717
ISI #: 000353979800009
ISSN: 1479-9723
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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