Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18920

Title: A single dose of sodium nitrate does not improve oral glucose tolerance in patients with type 2 diabetes mellitus
Authors: Cermak, Naomi
HANSEN, Dominique
Kouw, Imre
van Dijk, Jan-Willem
Blackwell, Jamie
Jones, Andrew
Gibala, Martin
van Loon, Luc
Issue Date: 2015
Citation: NUTRITION RESEARCH, 35 (8), p. 674-680
Abstract: Dietary nitrate supplementation has been proposed as an emerging treatment strategy for type 2 diabetes. We hypothesized that ingestion of a single bolus of dietary nitrate ingestion improves oral glucose tolerance in patients with type 2 diabetes. Seventeen men with type 2 diabetes (HbA1c: 7.3±0.2%) participated in a randomized crossover experiment. Subjects ingested a glucose beverage 2.5 h after consuming either sodium nitrate (0.15 mmol NaNO3-·kg-1) or a placebo solution. Venous blood samples were collected before ingestion of the glucose beverage and every 30 min thereafter during a 2-h period to assess postprandial plasma glucose and insulin concentrations. The results show that plasma nitrate and nitrite levels were increased after sodium nitrate as opposed to placebo ingestion (treatment-effect: P=0.001). Despite the elevated plasma nitrate and nitrite levels, ingestion of sodium nitrate did not attenuate the postprandial rise in plasma glucose and insulin concentrations (time x treatment interaction: P=0.41 for glucose, P=0.93 for insulin). Despite the lack of effect on oral glucose tolerance, basal plasma glucose concentrations measured 2.5 h after sodium nitrate ingestion were lower when compared with the placebo treatment (7.5±0.4 vs 8.3±0.4 mmol/L, respectively; P=0.04). We conclude that ingestion of a single dose of dietary nitrate does not improve subsequent oral glucose tolerance in patients with type 2 diabetes.
Notes: Correspondence: Luc J.C. van Loon, Ph.D. Faculty of Health, Medicine and Life Sciences Maastricht University P.O. Box 616, 6200 MD Maastricht The Netherlands Tel: +31 43 3881397 Fax: +31 43 3670976 E-mail: L.vanLoon@maastrichtuniversity.nl
URI: http://hdl.handle.net/1942/18920
DOI: 10.1016/j.nutres.2015.05.017
ISI #: 000359512400004
ISSN: 0271-5317
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
accept manuscript233.15 kBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.