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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18893

Title: Blunted regulation of adipocyte lipolysis by exercise-induced atrial natriuretic peptide in obese diabetic men
Authors: Verboven, Kenneth
Jocken, Johan W.E.
Blaak, Ellen E.
Hansen, Dominique
Issue Date: 2015
Citation: Cell symposium "Exercise Metabolism", Amsterdam, 12-14/07/2015
Abstract: Beside insulin and catecholamines, atrial natriuretic peptide (ANP) is a vital regulator of adipocyte lipolysis. As obesity is characterized by catecholamine resistance, no data are available on ANP sensitivity. The aim of this study was to investigate ex vivo lipolytic sensitivity of subcutaneous (SCAT) and visceral adipose tissue (VAT) for ANP in lean (n=13, BMI=23.9±1.1) and obese subjects (n=28, BMI=38.3±3.8), with or without type 2 diabetes (HbA1c ≥6.5%). Mature adipocytes were isolated and exposed to increasing ANP concentrations. ANP sensitivity was significantly higher in SCAT compared to VAT. Interestingly, maximal lipolytic response to ANP was significantly lower in the SCAT of diabetic obese, compared to lean subjects, accompanied by significantly higher expression of the scavenging type-C ANP receptor. This study shows that ANP regulated adipocyte lipolysis in obese diabetic men is blunted. Therefore, improving ANP sensitivity might be a way to improve body weight control and insulin sensitivity in obesity.
URI: http://hdl.handle.net/1942/18893
Category: C2
Type: Conference Material
Appears in Collections: Research publications

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