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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18891

Title: Some morphological substrates in the pathogenesis of arthritis.
Authors: VAN ZWIETEN, Koos Jaap
DE BAKKER, Bernadette
KOSTEN, Lauren
DE MUNTER, Stephanie
Issue Date: 2015
Citation: Knowledge for Growth 2015, FlandersBio's Annual Life Sciences Convention, 11th Edition, Ghent - Belgium, 21/05/2015
Abstract: In order to gain more insight into pathogeneses of joint diseases like Rheumatoid Arthritis (RA) and possibly also Osteoarthritis (OA), High Resolution Magnetic Resonance Imaging (HR-MRI) of the adult proximal interphalangeal (PIP)-joint in an otherwise normal anatomical specimen of the finger was analyzed. We also investigated the histology of a part of the PIP-joint capsule. In adult proximal interphalangeal joints, dorsal and palmar but also ulnar and radial synovial folds (also described as "fat pads" in other synovial joints) do persist, as our HR-MRI slices reveal. Such synovial folds (e.g., after micro-damage) may elicit chronic inflammatory processes that eventually lead to arthritis. In PIP collateral ligaments, we found neurofilaments and oval-shaped lamellated corpuscles (ø ≈ 120 μ). Supposedly acting as mechanoreceptors in finger motion, they may also produce cytokines and substance P, a neuropeptide involved in pain. These organs may also play a role in the pathogeneses of joint inflammation.
Notes: Recent research findings, based on several Master's Theses in Clinical Molecular Sciences from our Group of Functional Morphology, University of Hasselt, Belgium. Knowledge for Growth, FlandersBio, May 21, 2015, Ghent, Program Book Page 16, Therapeutics and Diagnostics - Inflammation, Immunology, Infectious and Eye Diseases : No. 52
URI: http://hdl.handle.net/1942/18891
Link to publication: http://knowledgeforgrowth.be/en/research-detail/some-morphological-substrates-in-the-pathogenesis-of-arthritis.
DOI: 10.13140/RG.2.1.1429.2009
Category: C2
Type: Conference Material
Appears in Collections: Research publications

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