www.uhasselt.be
DSpace

Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18761

Title: Reduced graphene oxide-based sensing platform for electric cell-substrate impedance sensing
Authors: LANCHE RADILLA, Ruben
Pachauri, Vivek
Koppenhoefer, Dieter
WAGNER, Patrick
Ingebrandt, Sven
Issue Date: 2014
Publisher: WILEY-V C H VERLAG GMBH
Citation: PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 211 (6), p. 1404-1409
Abstract: Graphene, with its unique electrical properties and biocompatibility, has become a material of choice for the development of biosensor platforms. In this study, a microelectrode array based on reduced graphene oxide (rGO) was constructed and used as a platform for electrical monitoring of cell-substrate adhesion. The rGO-based sensor arrays were designed in order to facilitate sensor pads comparable to the size of individual cells. The sensor chips were fabricated in a scalable manner via site-specific immobilization of graphene oxide flakes onto microelectrode pairs followed by reduction to rGO. The sensor chips were mounted on a measurement platform equipped with a fluidic cell. Electrical characteristics were recorded and field-effect behavior was confirmed. Sensors reacted to changes of pH value in the solution. Finally, as a proof-of-concept, the graphene oxide-based sensing platform was used for electrical cell-substrate impedance sensing of individual HEK293 cells in culture. Schematic view of the rGO-based sensor chip for electrical cell-substrate adhesion assays. (C) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Notes: [Lanche, Ruben; Pachauri, Vivek; Koppenhoefer, Dieter; Ingebrandt, Sven] Univ Appl Sci Kaiserslautern, Dept Informat & Microsyst Technol, D-66482 Zweibrucken, Germany. [Wagner, Patrick] Hasselt Univ, Inst Mat Res, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/18761
DOI: 10.1002/pssa.201330522
ISI #: 000337759000030
ISSN: 1862-6300
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
published version694.89 kBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.