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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18755

Title: Circulating vitamin D binding protein levels are not associated with relapses or with vitamin D status in multiple sclerosis
Authors: Smolders, Joost
PEELEN, Evelyn
Menheere, Paul
Damoiseaux, Jan
Hupperts, Raymond
Issue Date: 2014
Citation: MULTIPLE SCLEROSIS JOURNAL, 20 (4), p. 433-437
Abstract: Background: A low vitamin D status has been associated with multiple sclerosis (MS). Most circulating vitamin D metabolites are bound to vitamin D binding protein (DBP). Objectives: The purpose of this study was to explore whether there is an association between MS and DBP. Methods: We compared DBP concentrations in blood samples of controls (n = 30) and subjects with relapsing-remitting MS (RRMS) during remission (n = 29) and relapse (n = 15). Furthermore, we explored correlations of DBP with 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D levels (1,25(OH)(2)D), and the effect of high-dose vitamin D-3 supplementation on DBP levels in RRMS patients (n = 15). Results: DBP-concentration did not differ between the sub-groups measured, and there was no correlation between DBP and vitamin D metabolite concentration within the physiological range. Upon supplementation of high doses vitamin D-3, DBP concentration remained unaltered. After supplementation, serum 1,25(OH)(2)D(R = 0.517, p = 0.049), but not 25(OH)D, correlated positively with DBP. Conclusions: We found no association between DBP, MS, and vitamin D status within the physiological range. After high - dose vitamin D supplementation, DBP concentrations may be relevant for vitamin D metabolism.
Notes: Corresponding author: Joost Smolders, Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Meibergdreef 47, Amsterdam, 1105BA, The Netherlands. Email: smolders@gmail.com
URI: http://hdl.handle.net/1942/18755
DOI: 10.1177/1352458513500552
ISI #: 000337295300008
ISSN: 1352-4585
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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