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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18685

Title: Neurobehavioral performance in adolescents is inversely associated with traffic exposure
Authors: KICINSKI, Michal
Vermeir, Griet
Van Larebeke, Nicolas
Den Hond, Elly
Schoeters, Greet
BRUCKERS, Liesbeth
Sioen, Isabelle
ROELS, Harry
Baeyens, Willy
Viaene, Mineke K.
Issue Date: 2015
Citation: ENVIRONMENT INTERNATIONAL, 75, p. 136-143
Abstract: On the basis of animal research and epidemiological studies in children and elderly there is a growing concern that traffic exposure may affect the brain. The aim of our study was to investigate the association between traffic exposure and neurobehavioral performance in adolescents. We examined 606 adolescents. To model the exposure, we constructed a traffic exposure factor based on a biomarker of benzene (urinary trans,trans-muconic acid) and the amount of contact with traffic preceding the neurobehavioral examination (using distance-weighted traffic density and time spent in traffic). We used a Bayesian structural equation model to investigate the association between traffic exposure and three neurobehavioral domains: sustained attention, short-term memory, and manual motor speed. A one standard deviation increase in traffic exposure was associated with a 026 standard deviation decrease in sustained attention (95% credible interval: -0.02 to -0.51), adjusting for gender, age, smoking, passive smoking, level of education of the mother, socioeconomic status, time of the day, and day of the week. The associations between traffic exposure and the other neurobehavioral domains studied had the same direction but did not reach the level of statistical significance. The results remained consistent in the sensitivity analysis excluding smokers and passive smokers. The inverse association between sustained attention and traffic exposure was independent of the blood lead level. Our study in adolescents supports the recent findings in children and elderly suggesting that traffic exposure adversely affects the neurobehavioral function. (C) 2014 Elsevier Ltd. All rights reserved.
Notes: [Kicinski, Michal; Bijnens, Esmee; Roels, Harry A.; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. [Vermeir, Griet] Integrated Psychiat Ctr OPZ, Geel, Belgium. [Van Larebeke, Nicolas; Baeyens, Willy] Vrije Univ Brussel, Dept Analyt & Environm Chem, Brussels, Belgium. [Van Larebeke, Nicolas] Univ Ghent, Dept Radiotherapy & Nucl Med, B-9000 Ghent, Belgium. [Den Hond, Elly; Schoeters, Greet] Flemish Inst Technol Res Environm Risk & Hlth, Mol, Belgium. [Schoeters, Greet] Univ Antwerp, Dept Biomed Sci, B-2020 Antwerp, Belgium. [Bruckers, Liesbeth] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, B-3590 Diepenbeek, Belgium. [Sioen, Isabelle] Univ Ghent, Dept Publ Hlth, Ghent, Belgium. [Roels, Harry A.] Catholic Univ Louvain, Louvain Ctr Toxicol & Appl Pharmacol LTAP, B-1200 Brussels, Belgium. [Viaene, Mineke K.] Sint Dimphna Hosp, Dept Neurol, Geel, Belgium. [Nawrot, Tim S.] Katholieke Univ Leuven, Sch Publ Hlth Occupat & Environm Med, Leuven, Belgium.
URI: http://hdl.handle.net/1942/18685
DOI: 10.1016/j.envint.2014.10.028
ISI #: 000348746600013
ISSN: 0160-4120
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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