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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18659

Title: Herpes zoster is associated with herpes simplex and other infections in under 60 year-olds
Authors: OGUNJIMI, Benson
Buntinx, Frank
Bartholomeeusen, Stefaan
Terpstra, Ita
De Haes, Inke
Willem, Lander
Elli, Steven
Bilcke, Joke
Van Damme, Pierre
Coenen, Samuel
Beutels, Philippe
Issue Date: 2015
Citation: JOURNAL OF INFECTION, 70 (2), p. 171-177
Abstract: Objectives: We assessed the association between herpes zoster (HZ) and herpes simplex (HS) occurrence whilst controlling for risk factors of HZ. Methods: Using a Belgian general practitioner network, a retrospective cohort study with 3736 HZ patients and 14,076 age-gender-practice matched controls was performed, covering over 1.5 million patient-years. Multiple logistic regression was used with HZ as outcome and several diagnoses (malignancy, depression, diabetes mellitus, auto-immune diseases, asthma, multiple sclerosis, HIV, fractures), medications (systemic corticosteroids, biologicals, vaccination), HS and other infections as variables. Results: HS was significantly associated with HZ for all analysed time intervals (up to five years) post HZ (OR of 3.51 [2.09 5.88] 95%CI one year post HZ) and to a lesser extent for time ranges pre HZ. Registration of other infections was significantly associated with HZ in all time intervals pre and post HZ (OR up to 1.37). Malignancy up to five years pre HZ, depression up to one year pre or post HZ, fractures up to two years pre HZ, asthma, auto-immune diseases, and immunosuppressive medication one year pre or post HZ were also associated with HZ. Conclusions: HZ and HS occurrences are significantly associated and potentially share a common susceptibility beyond the known risk factors. (C) 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
Notes: [Ogunjimi, Benson; Terpstra, Ita; De Haes, Inke; Willem, Lander; Bilcke, Joke; Beutels, Philippe] Univ Antwerp, Ctr Hlth Econ Res & Modeling Infect Dis CHERMID, Vaccine & Infect Dis Inst VAXINFECTIO, B-2610 Antwerp, Belgium. [Ogunjimi, Benson] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BIOST, B-3590 Diepenbeek, Belgium. [Buntinx, Frank; Bartholomeeusen, Stephaan; Elli, Steven] Catholic Univ Louvain, Dept Gen Practice & Intego Registry, B-3000 Louvain, Belgium. [Buntinx, Frank] Univ Maastricht, Res Inst Caphri, NL-6229 Maastricht, Netherlands. [Van Damme, Pierre] Univ Antwerp, CEV, Vaccine & Infect Dis Inst VAXINFECTIO, B-2610 Antwerp, Belgium. [Coenen, Samuel] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Lab Med Microbiol, B-2610 Antwerp, Belgium. [Coenen, Samuel] Univ Antwerp, Ctr Gen Practice, Vaccine & Infect Dis Inst VAXINFECTIO, B-2610 Antwerp, Belgium. [Beutels, Philippe] Univ New S Wales, Sch Publ Hlth & Community Med, Sydney, NSW 2052, Australia.
URI: http://hdl.handle.net/1942/18659
DOI: 10.1016/j.jinf.2014.08.016
ISI #: 000348039900008
ISSN: 0163-4453
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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