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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18656

Title: Internal exposure to organochlorine pollutants and cadmium and self-reported health status: A prospective study
Authors: Van Larebeke, Nik
Sioen, Isabelle
Den Hond, Elly
Nelen, Vera
Van de Mieroop, Els
BRUCKERS, Liesbeth
Schoeters, Greet
Baeyens, Willy
Issue Date: 2015
Abstract: In this paper, based on the Flemish biomonitoring programs, we describe the associations between internal exposure to organochlorine pollutants and to cadmium (measured in 2004-2005 for adults aged 50-65 years) and self-reported health status obtained through a questionnaire in November 2011. Dioxin-like activity in serum showed a significant positive association with risk of cancer for women. After adjustment for confounders and covariates, the odds ratio for an exposure equal to the 90th percentile was 2.4 times higher than for an exposure equal to the 10th percentile. For both men and women dioxin-like activity and serum hexachlorobenzene (HCB) showed a significant positive association with risk of diabetes and of hypertension. Detailed analysis suggested that an increase in BMI might be part of the mechanism through which HCB contributes to diabetes and hypertension. Serum dichlorodiphenyldichloroethylene (p,p'-DDE) concentration showed a significant positive association with diabetes and hypertension in men, but not in women. Serum polychlorinated biphenyl (PCB) 118 showed a significant positive association with diabetes in both men and women, and after adjustment for correlated exposures, also with hypertension in men. Urinary cadmium concentrations showed a significant positive association with hypertension. Urinary cadmium concentrations were (in 2004-2005) significantly higher in persons who felt in less than good health (in 2011) than in persons who felt in very good health. After adjustment for correlated exposures (to HCB, p,p'-DDE and PCB118) marker PCBs showed a significant negative association with diabetes and hypertension. Serum p,p'-DDE showed in men a significant negative association with risk of diseases based on atheromata. Our findings suggest that exposure to pollutant S can lead to an important increase in the risk of diseases such as cancer, diabetes and hypertension. Some pollutants may possibly also decrease the risk of some health problems, although this requires confirmation by other approaches. (C) 2014 Elsevier GmbH. All rights reserved.
Notes: [Van Larebeke, Nik; Baeyens, Willy] Free Univ Brussels VUB, Dept Analyt & Environm Chem ANCH, B-1050 Brussels, Belgium. [Sioen, Isabelle] Univ Ghent, Dept Publ Hlth, B-9000 Ghent, Belgium. [Den Hond, Elly; Schoeters, Greet] Flemish Inst Technol Res VITO, B-2400 Mol, Belgium. [Nelen, Vera; Van de Mieroop, Els] Prov Inst Hyg, B-2000 Antwerp, Belgium. [Nawrot, Tim] Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. [Nawrot, Tim] Katholieke Univ Leuven, Sch Publ Hlth Occupat & Environm Med, B-3000 Leuven, Belgium. [Bruckers, Liesbeth] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, B-3500 Hasselt, Belgium.
URI: http://hdl.handle.net/1942/18656
DOI: 10.1016/j.ijheh.2014.11.002
ISI #: 000350073700007
ISSN: 1438-4639
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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