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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18414

Title: Interferon-alpha-induced depressive symptoms are related to changes in the cytokine network but not to cortisol
Authors: Wichers, M.C.
Kenis, G.
Koek, G.H.
Robaeys, Geert
Nicolson, N.A.
Maes, M.
Issue Date: 2007
Citation: JOURNAL OF PSYCHOSOMATIC RESEARCH, 62 (2), p. 207-214
Abstract: Objective Proinflammatory cytokines have the potential to activate the hypothalamo-pituitary-adrenocortical (HPA) axis, and HPA axis hyperactivity is also encountered in depression. Therefore, the induction of depressive symptoms by interferon-α (IFN-α) may be mediated by changes in the cytokine network and the HPA axis. Methods In 17 hepatitis C patients undergoing IFN-α treatment, depressive symptoms were measured using the Montgomery–Asberg Depression Rating Scale (MADRS). In addition, serum cytokine concentrations were measured. Saliva was collected five times over the course of a day in order to assess daily average cortisol (DAC) and awakening response. Assessments were carried out at baseline and six later time points after starting treatment. Results During treatment, the increases in the MADRS were significantly and positively correlated with soluble interleukin (IL)-2 receptor, tumor necrosis factor α (TNF-α), and IL-6. There were no significant associations between the DAC or cortisol awakening response with the MADRS score. Conclusion Results suggest a clear connection between IFN-α-induced depressive symptoms and cytokine concentrations, but not cortisol.
URI: http://hdl.handle.net/1942/18414
DOI: 10.1016/j.jpsychores.2006.09.007
ISSN: 0022-3999
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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