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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18297

Title: The course of anaemia in children and adolescents with Crohn's disease included in a prospective registry
Authors: Van Biervliet, Stephanie
Smets, Francoise
Hofmann, Ilse
Degreef, Elisabeth
Hauser, Bruno
Bontems, Patrick
Vande Velde, Saskia
Arts, Wim
Paquot, Isabelle
Alliet, Philippe
Bossuyt, Peter
Louis, Edouard
Baert, Filip
Bauraind, Olivia
Rahier, Jean-Francois
Veereman, Gigi
Issue Date: 2015
Publisher: SPRINGER
Abstract: Aim The aim of this study is to determine the prevalence and evolution of anaemia in prospectively followed children and adolescents diagnosed with Crohn's disease (CD). Methods The BELCRO registry (inclusion May 2008-April 2010), describing current clinical treatment practice of children diagnosed with CD, provided data on age, height, body mass index (BMI), paediatric Crohn's disease activity index (PCDAI), therapy and haemoglobin (Hb) at diagnosis 12 and 24 months follow-up. Anaemia was defined as Hb < -2 sd, while severe anaemia was defined as Hb < -4 sd. Patients were classified as child a parts per thousand currency sign13 and adolescent > 13 years of age. Result Ninety-six were included, 13 dropped out due to insufficient Hb data (37 females/46 males; median age 13.3 years, range 2.2-17.8 years). At diagnosis, the median Hb sd was -2.66 (-8.4; 1.07) and was correlated with the PCDAI (p = 0.013). At diagnosis, 51/83 (61 %) were anaemic and all had active disease. Hb z-score significantly improved (p < 0.0001) but 26/68 (38 %) remained anaemic at 12 months and 29/76 (38 %) at 24 months of follow-up. The correlation to the PCDAI disappeared. At 24 months, children were more likely to be anaemic. There was no difference in iron dose nor duration of iron supplements between children and adolescents. Iron treatment was more readily given to patients presenting with anaemia. Hb did not differ between patients with (n = 28) or without iron supplements. Half of the patients with persisting anaemia were given iron supplements, of which, only three were given intravenously. Conclusion Anaemia remains an important extra-intestinal manifestation of CD in children. Physicians, lacking optimal treatment strategies, undertreat their patients.
Notes: [Van Biervliet, Stephanie; Vande Velde, Saskia] Ghent Univ Hosp, B-9000 Ghent, Belgium. [Smets, Francoise] Clin Univ St Luc, B-1200 Brussels, Belgium. [Hofmann, Ilse] Katholieke Univ Leuven, Leuven, Belgium. [Degreef, Elisabeth; Hauser, Bruno; Veereman, Gigi] UZ Brussel, Brussels, Belgium. [Bontems, Patrick] Univ Libre Bruxelles, Hop Univ Enfants Reine Fabiola, Brussels, Belgium. [Arts, Wim] Ziekenhuis Oost Limburg, Genk, Belgium. [Paquot, Isabelle] Clin Esperance, Montegneem, Belgium. [Alliet, Philippe] Jessa Hosp, Hasselt, Belgium. [Bossuyt, Peter] Imelda Ziekenhuis, Bonheiden, Belgium. [Louis, Edouard] Ctr Hosp Univ Liege, Liege, Belgium. [Baert, Filip] Heilig Hart Ziekenhuis, Roeselare, Belgium. [Bauraind, Olivia] Hop St Pierre & Erasme, Brussels, Belgium. [Rahier, Jean-Francois] CHU Mt Godinne, Namur, Belgium.
URI: http://hdl.handle.net/1942/18297
DOI: 10.1007/s00384-014-2042-4
ISI #: 000347152300006
ISSN: 0179-1958
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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