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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18209

Title: Cytomegalovirus: a culprit or protector in multiple sclerosis?
Authors: VANHEUSDEN, Marjan
't HART, Bert A.
Hellings, Niels
Issue Date: 2015
Citation: TRENDS IN MOLECULAR MEDICINE, 21 (1), p. 16-23
Abstract: Multiple sclerosis (MS) is a chronic disabling autoimmune disease of the central nervous system (CNS). Cytomegalovirus (CMV), a β herpes virus, may have a detrimental or beneficial role in MS pathology. Accumulating evidence indicates that CMV contributes to MS disease via interplay of different mechanisms such as molecular mimicry, bystander activation, and epitope spreading. The activation and expansion of a specific T cell subset, CD4+CD28null T cells, via CMV infection could also contribute to MS pathology. Various additional observations also indicate a protective effect of CMV on autoimmune diseases. CMV immune evasion may mitigate the autoimmune reactions and proinflammatory milieu that contribute to MS.
Notes: Corresponding author: Hellings, N. (niels.hellings@uhasselt.be).
URI: http://hdl.handle.net/1942/18209
DOI: 10.1016/j.molmed.2014.11.002
ISI #: 000347862800003
ISSN: 1471-4914
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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