Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18205

Title: Subcortical volumetric changes across the adult lifespan: subregional thalamic atrophy accounts for age-related sensorimotor performance declines
Authors: Serbruyns, Leen
Leunissen, Inge
Huysmans, Toon
Van Ruitenbeek, Peter
Sijbers, Jan
Swinnen, Stephan
Issue Date: 2015
Citation: CORTEX. 65, p. 128-138
Abstract: Even though declines in sensorimotor performance during healthy aging have been documented extensively, its underlying neural mechanisms remain unclear. Here, we explored whether age-related subcortical atrophy plays a role in sensorimotor performance declines, and particularly during bimanual manipulative performance (Purdue Pegboard Test). The thalamus, putamen, caudate and pallidum of 91 participants across the adult lifespan (ages 20 – 79 years) were automatically segmented. In addition to studying age-related changes in the global volume of each subcortical structure, local deformations within these structures, indicative of subregional volume changes, were assessed by means of recently developed shape analyses. Results showed widespread age-related global and subregional atrophy, as well as some notable subregional expansion. Even though global atrophy failed to explain the observed performance declines with aging, shape analyses indicated that atrophy in left and right thalamic subregions, specifically subserving connectivity with the premotor, primary motor and somatosensory cortical areas, mediated the relation between aging and performance decline. It is concluded that subregional volume assessment by means of shape analyses offers a sensitive tool with high anatomical resolution in the search for specific age-related associations between brain structure and behavior.
Notes: Swinnen, SP (reprint author), Katholieke Univ Leuven, Dept Kinesiol, Movement Control & Neuroplast Res Grp, Motor Control Lab,Biomed Sci Grp, Tervuursevest 101, B-3001 Heverlee, Belgium. Stephan.Swinnen@faber.kuleuven.be
URI: http://hdl.handle.net/1942/18205
DOI: 10.1016/j.cortex.2015.01.003
ISI #: 000353739300011
ISSN: 0010-9452
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
N/A714.49 kBAdobe PDF
published version1.31 MBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.