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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18203

Title: Altered signaling for mitochondrial and myofibrillar biogenesis in skeletal muscles of multiple sclerosis patients
Authors: Hansen, Dominique
Wens, Inez
Vandenabeele, Frank
Verboven, Kenneth
Eijnde, Bert O.
Issue Date: 2015
Citation: Translational Research. 166 (1), p. 70-79
Abstract: Patients with MS (pwMS) experience muscle weakness and lowered muscle oxidative capacity. To explore the etiology for the development of such muscle phenotype we studied skeletal muscle AMP-activated protein kinase (phospho-AMPKα, governing mitochondrial biogenesis) and mammalian target of rapamycin (phospho-mTOR, governing myofibrillar biogenesis) phosphorylation in pwMS. After assessment of body composition, muscle strength, exercise tolerance and muscle fiber type, muscle phospho-AMPKα and phosphomTOR was assessed in 14 pwMS and 10 healthy controls (part 1). Next, an endurance exercise bout was executed by 9 pwMS and 7 healthy subjects, with assessment of changes in muscle phospho-AMPKα and phospho-mTOR (part 2). Elevated basal muscle phosphoAMPKα and phospho-mTOR was present in MS (p<0.01) and independently related to MS. Correlations between muscle phospho-AMPKα or phospho-mTOR and whole-body fat mass, peak oxygen uptake and expanded disability status scale (p<0.05) were found. After endurance exercise muscle phospho-AMPKα and phospho-mTOR remained elevated in pwMS (p<0.01). Muscle signaling cascades for mitochondrial and myofibrillar biogenesis are altered in MS and related to impairment and disability level. These findings indicate a link between muscle signaling cascades and level of disability/impairment, and thus may open a new area for the development of novel therapies for peripheral muscle impairment in MS.
Notes: Address correspondence: Dominique Hansen, PhD Hasselt University, Faculty of Medicine and Life Sciences Agoralaan, Building A, 3590 Diepenbeek, Belgium Dominique.hansen@uhasselt.be Tel 0032 (0)11 294978 Fax 0032 (0)11 269329
URI: http://hdl.handle.net/1942/18203
DOI: 10.1016/j.trsl.2015.01.006
ISI #: 000356317700007
ISSN: 1931-5244
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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