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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18135

Title: Multiple Sclerosis Affects Skeletal Muscle Characteristics
Authors: WENS, Inez
Dalgas, Ulrik
Krekels, Maartje
Grevendonk, Lotte
Issue Date: 2014
Citation: PLOS ONE, 9 (9)
Abstract: Background: The impact of multiple sclerosis (MS) on skeletal muscle characteristics, such as muscle fiber cross sectional area (CSA), fiber type proportion, muscle strength and whole muscle mass, remains conflicting. Methods: In this cross sectional study, body composition and muscle strength of the quadriceps were assessed in 34 MS (EDSS: 2.560.19) patients and 18 matched healthy controls (HC). Hereafter a muscle biopsy (m.vastus lateralis) was taken. Results: Compared to HC, mean muscle fiber CSA of all fibers, as well as CSA of type I, II and IIa fibers were smaller and muscle strength of the quadriceps was lower in MS patients. Whole body composition was comparable between groups. However, compared to HC, the biopsied leg tended to have a higher fat percentage (p = 0.1) and a lower lean mass (p = 0.06) in MS patients. Conclusion: MS seems to negatively influence skeletal muscle fiber CSA, muscle strength and muscle mass of the lower limbs of mildly affected MS patients. This emphasises the need for rehabilitation programs focusing on muscle preservation of the lower limb. Trial Registration: ClinicalTrials.gov NCT01845896
Notes: [Wens, Inez; Vandenabeele, Frank; Krekels, Maartje; Grevendonk, Lotte; Eijnde, Bert O.] Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Inst, REVAL Rehabil Res Ctr, Hasselt, Belgium. [Dalgas, Ulrik] Aarhus Univ, Dept Publ Hlth, Sect Sport Sci, Aarhus C, Denmark.
URI: http://hdl.handle.net/1942/18135
DOI: 10.1371/journal.pone.0108158
ISI #: 000345745400045
ISSN: 1932-6203
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

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