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|Title: ||Multiple Sclerosis Affects Skeletal Muscle Characteristics|
|Authors: ||WENS, Inez|
EIJNDE, OP 'T Bert
|Issue Date: ||2014|
|Publisher: ||PUBLIC LIBRARY SCIENCE|
|Citation: ||PLOS ONE, 9 (9)|
|Abstract: ||Background: The impact of multiple sclerosis (MS) on skeletal muscle characteristics, such as muscle fiber cross sectional
area (CSA), fiber type proportion, muscle strength and whole muscle mass, remains conflicting.
Methods: In this cross sectional study, body composition and muscle strength of the quadriceps were assessed in 34 MS
(EDSS: 2.560.19) patients and 18 matched healthy controls (HC). Hereafter a muscle biopsy (m.vastus lateralis) was taken.
Results: Compared to HC, mean muscle fiber CSA of all fibers, as well as CSA of type I, II and IIa fibers were smaller and
muscle strength of the quadriceps was lower in MS patients. Whole body composition was comparable between groups.
However, compared to HC, the biopsied leg tended to have a higher fat percentage (p = 0.1) and a lower lean mass (p = 0.06) in MS patients.
Conclusion: MS seems to negatively influence skeletal muscle fiber CSA, muscle strength and muscle mass of the lower
limbs of mildly affected MS patients. This emphasises the need for rehabilitation programs focusing on muscle preservation
of the lower limb.
Trial Registration: ClinicalTrials.gov NCT01845896|
|Notes: ||[Wens, Inez; Vandenabeele, Frank; Krekels, Maartje; Grevendonk, Lotte; Eijnde, Bert O.] Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Inst, REVAL Rehabil Res Ctr, Hasselt, Belgium. [Dalgas, Ulrik] Aarhus Univ, Dept Publ Hlth, Sect Sport Sci, Aarhus C, Denmark.|
|ISI #: ||000345745400045|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2016|
|Appears in Collections: ||Research publications|
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