Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18065

Title: Targets of the humoral autoimmune response in multiple sclerosis.
Authors: FRAUSSEN, Judith
DE BOCK, Laura
SOMERS, Veerle
Issue Date: 2014
Citation: Autoimmunity reviews, 13 (11), p. 1126-1137
Abstract: Multiple sclerosis (MS) is an inflammatory disorder of the central nervous system (CNS) with heterogeneous clinical, genetic and pathophysiological characteristics. The establishment of reliable biomarkers for diagnosis, prognosis and treatment of MS has therefore proven to be very difficult. During the last decades, mounting evidence has been collected for the involvement of B cells and antibodies in MS pathogenesis. A wide variety of autoantibodies has been described in MS and these autoantibodies could be useful biomarkers for MS. Since demyelination is a key component of MS pathogenesis, myelin antigens were first investigated as primary targets of autoantibodies in MS. More recently, it became evident that the humoral autoimmune response is not restricted to myelin but is much more widespread throughout the brain. Autoantibodies are formed against different CNS cell types, including neurons, oligodendrocytes and astrocytes, and even immune cells, indicating the complex heterogeneity of the disease. In this review, we give an extensive overview of the known autoantibody targets in MS, not according to the traditional subdivision of myelin and non-myelin components but according to each of the affected cell types, including the most recently described target antigens.
Notes: Somers, V (reprint author), Hasselt Univ, Biomed Res Inst, Agoralaan,Bldg C, B-3590 Diepenbeek, Belgium. veerle.somers@uhasselt.be
URI: http://hdl.handle.net/1942/18065
DOI: 10.1016/j.autrev.2014.07.002
ISI #: 000345476700009
ISSN: 1568-9972
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
published version743.04 kBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.