Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18058

Title: Blood pressure changes in association with black carbon exposure in a panel of healthy adults are independent of retinal microcirculation.
Authors: LOUWIES, Tijs
Nawrot, Tim
Cox, Bianca
Dons, Evi
Penders, Joris
Int Panis, Luc
De Boever, Patrick
Issue Date: 2015
Abstract: Exposure to ambient particulate matter and elevated blood pressure are risk factors for cardiovascular morbidity and mortality. Microvascular changes might be an important pathway in explaining the association between air pollution and blood pressure. The objective of the study was to evaluate the role of the retinal microcirculation in the association between black carbon (BC) exposure and blood pressure.We estimated subchronic BC exposure based on 1-week personal measurements (μAethalometer, AethLabs) in 55 healthy nurses. Blood pressure and retinal microvasculature were measured on four different days (range: 2–4) during this week.Subchronic BC exposure averaged (± SD) 1334 ± 631 ng/m3 and ranged from 338 ng/m3 to 3889 ng/m3. An increased exposure of 631 ng/m3 BC was associated with a 2.77 mm Hg (95% CI: 0.39 to 5.15, p = 0.027) increase in systolic blood pressure, a 2.35 mm Hg (95% CI: 0.52 to 4.19, p = 0.016) increase in diastolic blood pressure and with 5.65 μm (95% CI: 1.33 to 9.96, p = 0.014) increase in central retinal venular equivalent. Mediation analysis failed to reveal an effect of retinal microvasculature in the association between blood pressure and subchronic BC exposure.In conclusion, we found a positive association between blood pressure and subchronic black carbon exposure in healthy adults. This finding adds evidence to the association between black carbon exposure and cardiovascular health effects, with elevated blood pressure as a plausible intermediate effector. Our results suggest that the changes in a person's blood pressure as a result of subchronic black carbon exposure operate independently of the retinal microcirculation.
Notes: De Boever, P (reprint author), VITO, Vlasmeer 7, B-2400 Mol, Belgium. patrick.deboever@vito.be
URI: http://hdl.handle.net/1942/18058
Link to publication: https://www.researchgate.net/publication/268695179_Blood_pressure_changes_in_association_with_black_carbon_exposure_in_a_panel_of_healthy_adults_are_independent_of_retinal_microcirculation
DOI: 10.1016/j.envint.2014.11.006
ISI #: 000348746600007
ISSN: 0160-4120
Category: A1
Type: Journal Contribution
Validation: ecoom, 2016
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
published version608.18 kBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.