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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18046

Title: Validating cone-beam computed tomography for peri-implant bone morphometric analysis
Authors: HUANG, Yanru
Van Dessel, Jeroen
Depypere, Maarten
EzEldeen, Mostafa
Iliescu, Alexandru Andrei
Dos Santos, Emanuela
Jacobs, Reinhilde
Issue Date: 2014
Citation: BONE RESEARCH, 2
Abstract: Cone-beam computed tomography (CBCT) has been recently used to analyse trabecular bone structure around dental implants. To validate the use of CBCT for three-dimensional (3D) peri-implant trabecular bone morphometry by comparing it to two-dimensional (2D) histology, 36 alveolar bone samples (with implants n=27 vs. without implants n=9) from six mongrel dogs, were scanned ex vivo using a high-resolution (80 mu m) CBCT. After scanning, all samples were decalcified and then sectioned into thin histological sections (similar to 6 mu m) to obtain high contrast 2D images. By using CT An imaging software, bone morphometric parameters including trabecular number (Tb.N), thickness (Tb.Th), separation (Tb.Sp) and bone volume fraction (BV/TV) were examined on both CBCT and corresponding histological images. Higher Tb. Th and Tb. Sp, lower BV/TV and Tb.N were found on CBCT images (P<0.001). Both measurements on the peri-implant trabecular bone structure showed moderate to high correlation (r=0.65-0.85). The Bland-Altman plots showed strongest agreement for Tb.Th followed by Tb.Sp, Tb.N and BV/TV, regardless of the presence of implants. The current findings support the assumption that peri-implant trabecular bone structures based on high-resolution CBCT measurements are representative for the underlying histological bone characteristics, indicating a potential clinical diagnostic use of CBCT-based peri-implant bone morphometric characterisation.
Notes: [Huang, Yan; Van Dessel, Jeroen; EzEldeen, Mostafa; Jacobs, Reinhilde] Univ Leuven, Fac Med, Dept Imaging & Pathol, OMFS IMPATH Res Grp, Leuven, Belgium. [Huang, Yan; Van Dessel, Jeroen; EzEldeen, Mostafa; Jacobs, Reinhilde] Univ Hosp Leuven, Leuven, Belgium. [Huang, Yan] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610064, Peoples R China. [Depypere, Maarten] Katholieke Univ Leuven, ESAT PSI, Leuven, Belgium. [Iliescu, Alexandru Andrei] UMF Craiova, Fac Dent, Craiova, Romania. [Dos Santos, Emanuela] Pontificia Univ Catolica Parana, Sch Dent, Curitiba, Parana, Brazil. [Lambrichts, Ivo] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium. [Liang, Xin] Dalian Med Univ, Sch Stomatol, Dalian, Peoples R China.
URI: http://hdl.handle.net/1942/18046
DOI: 10.1038/boneres.2014.10
ISI #: 000344998000001
ISSN: 2095-4700
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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