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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18038

Title: A medical image-based graphical platform-Features, applications and relevance for brachytherapy
Authors: Fonseca, Gabriel P.
RENIERS, Brigitte
Landry, Guillaume
White, Shane
Bellezzo, Murillo
Antunes, Paula C.G.
de Sales, Camila P.
Welteman, Eduardo
Yoriyaz, Helio
Verhaegen, Frank
Issue Date: 2014
Citation: BRACHYTHERAPY, 13 (6), p. 632-639
Abstract: PURPOSE: Brachytherapy dose calculation is commonly performed using the Task Group-No 43 Report-Updated protocol (TG-43U1) formalism. Recently, a more accurate approach has been proposed that can handle tissue composition, tissue density, body shape, applicator geometry, and dose reporting either in media or water. Some model-based dose calculation algorithms are based on Monte Carlo (MC) simulations. This work presents a software platform capable of processing medical images and treatment plans, and preparing the required input data for MC simulations. METHODS AND MATERIALS: The A Medical Image-based Graphical platfOrm Brachytherapy module (AMIGOBrachy) is a user interface, coupled to the MCNP6 MC code, for absorbed dose calculations. The AMIGOBrachy was first validated in water for a high-dose-rate Ir-192 source. Next, dose distributions were validated in uniform phantoms consisting of different materials. Finally, dose distributions were obtained in patient geometries. Results were compared against a treatment planning system including a linear Boltzmann transport equation (LBTE) solver capable of handling nonwater heterogeneities. RESULTS: The TG-43U1 source parameters are in good agreement with literature with more than 90% of anisotropy values within 1%. No significant dependence on the tissue composition was observed comparing MC results against an LBTE solver. Clinical cases showed differences up to 25%, when comparing MC results against TG-43U1. About 92% of the voxels exhibited dose differences lower than 2% when comparing MC results against an LBTE solver. CONCLUSION: The AMIGOBrachy can improve the accuracy of the TG-43U1 dose calculation by using a more accurate MC dose calculation algorithm. The AMIGOBrachy can be incorporated in clinical practice via a user-friendly graphical interface. (C) 2014 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
Notes: [Fonseca, Gabriel P.; Bellezzo, Murillo; Antunes, Paula C. G.; Yoriyaz, Helio] Inst Pesquisas Energet & Nucl IPEN, CNEN SP, Ctr Engn Nucl, Sao Paulo, Brazil. [Fonseca, Gabriel P.; Reniers, Brigitte; Landry, Guillaume; White, Shane; Verhaegen, Frank] Maastricht Univ, Med Ctr, GROW Sch Oncol & Dev Biol, Dept Radiat Oncol MAASTRO, NL-6201 BN Maastricht, Netherlands. [Reniers, Brigitte] Hasselt Univ, Ctr Environm Sci, Res Grp NuTeC, Diepenbeek, Belgium. [Landry, Guillaume] Univ Munich, Dept Med Phys, Garching, Germany. [de Sales, Camila P.] Univ Sao Paulo, Inst Radiol, Hosp Clin, HC FMUSP, Sao Paulo, Brazil. [Welteman, Eduardo] Univ Sao Paulo, Fac Med, HC FMUSP, Sao Paulo, Brazil. [Verhaegen, Frank] McGill Univ, Dept Oncol, Med Phys Unit, Montreal, PQ, Canada.
URI: http://hdl.handle.net/1942/18038
DOI: 10.1016/j.brachy.2014.07.004
ISI #: 000344137000016
ISSN: 1538-4721
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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