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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18031

Title: A case of HPV-53-related cervical cancer in an elderly patient
Authors: Lieveld, Marusya
PADALKO, Elizaveta
Praet, Marleen
Broeck, Davy Vanden
Issue Date: 2014
Citation: Clinical Interventions in Aging, 9, p. 1933-1934
Abstract: Zappacosta et al1 recently published a case report concerning a human papillomavirus (HPV)-positive invasive cervical cancer in a 79-year-old women who had a history of normal Pap smears. In this article, Anyplex II HPV28 (Seegene) is used for HPV genotyping of formalin-fixed paraffin embedded (FFPE) tissue, liquid based cytology (LBC) specimens and urine samples. It is suggested that HPV53 is present exclusively in the cervical cancer cells, lymph node metastases, and atypical urinary cells of one single case while the surrounding CIN2+ tissue revealed ten different HPV strains. Unfortunately, the HPV genotype results for lymph nodes and urinary cells are not presented while these results underline the potential role of HPV53 in oncogenesis. Moreover, it is generally accepted that one lesion is caused by one HPV infection, detection of multiple HPV types thus indicates the presence of multiple infections,2 suggesting that this patient may have several lesions.
Notes: [Lieveld, Marusya; Broeck, Davy Vanden] Ghent Univ Hosp, Dept Urogynaecol, Ghent, Belgium. [Padalko, Elizaveta] Ghent Univ Hosp, Dept Clin Chem Microbiol & Immunol, Ghent, Belgium. [Padalko, Elizaveta] Hasselt Univ, Sch Life Sci, Diepenbeek, Belgium. [Praet, Marleen] Ghent Univ Hosp, N Goormaghtigh Inst Pathol, Ghent, Belgium.
URI: http://hdl.handle.net/1942/18031
DOI: 10.2147/CIA.S71262
ISI #: 000344921300001
ISSN: 1178-1998
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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