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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18029

Title: Oncostatin M Reduces Lesion Size and Promotes Functional Recovery and Neurite Outgrowth After Spinal Cord Injury
Authors: Slaets, Helena
NELISSEN, Sofie
JANSSENS, Kris
VIDAL VERA, Pia
LEMMENS, Evi
STINISSEN, Piet
HENDRIX, Sven
HELLINGS, Niels
Issue Date: 2014
Publisher: HUMANA PRESS INC
Citation: MOLECULAR NEUROBIOLOGY, 50 (3), p. 1142-1151
Abstract: The family of interleukin (IL)-6 like cytokines plays an important role in the neuroinflammatory response to injury by regulating both neural as well as immune responses. Here, we show that expression of the IL-6 family member oncostatin M (OSM) and its receptor is upregulated after spinal cord injury (SCI). To reveal the relevance of increased OSM signaling in the pathophysiology of SCI, OSM was applied locally after spinal cord hemisection in mice. OSM treatment significantly improved locomotor recovery aftermild and severe SCI. Improved recovery in OSM treated mice was associated with a reduced lesion size. OSM significantly diminished astrogliosis and immune cell infiltration. Thus, OSM limits secondary damage after CNS trauma. In vitro viability assays demonstrated that OSM protects primary neurons in culture from cell death, suggesting that the underlying mechanism involves direct neuroprotective effects of OSM. Furthermore, OSM dose-dependently promoted neurite outgrowth in cultured neurons, indicating that the cytokine plays an additional role in CNS repair. Indeed, our in vivo experiments demonstrate that OSM treatment increases plasticity of serotonergic fibers after SCI. Together, our data show that OSMis produced at the lesion site, where it protects the CNS from further damage and promotes recovery.
Notes: [Slaets, Helena; Janssens, Kris; Stinissen, Piet; Hellings, Niels] Transnat Univ Limburg, Hasselt Univ, Biomed Res Inst, Sch Life Sci, Diepenbeek, Belgium. [Nelissen, Sofie; Vidal, Pia M.; Lemmens, Evi; Hendrix, Sven] Hasselt Univ, Dept Morphol, Diepenbeek, Belgium. [Nelissen, Sofie; Vidal, Pia M.; Lemmens, Evi; Hendrix, Sven] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Nelissen, Sofie] Transnat Univ Limburg, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/18029
DOI: 10.1007/s12035-014-8795-5
ISI #: 000344865700033
ISSN: 0893-7648
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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