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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17973

Title: Cardiovascular Risk Factor Analysis in Patients with a Recent Clinical Fracture at the Fracture Liaison Service
Authors: Wyers, Caroline E.
Vranken, Lisanne
van der Velde, Robert Y.
Janzing, Heinrich M. J.
Morrenhof, J. Wim
Issue Date: 2014
Abstract: Patients with a low bone mineral density have an increased risk of cardiovascular diseases (CVD) and venous thromboembolic events (VTE). The aim of our retrospective chart review was to investigate the prevalence of CVD, VTE, hypertension ( HT), and diabetes mellitus type 2 (DM2) in patients with a recent clinical fracture visiting the Fracture Liaison Service (FLS). Out of 3057 patients aged 50-90 years, 1359 consecutive patients, who agreed and were able to visit the FLS for fracture risk evaluation, were included (71.7% women; mean age 65.2 yrs). Based on medical history, 29.9% had a history of CVD (13.7%), VTE (1.7%), HT (14.9%), and DM2 (7.1%) or a combination. Their prevalence increased with age (21% in patients aged 50-59 years to 48% in patients aged >80 years) and was higher in men than in women (36% versus 27%), but independent of bone mineral density and fracture type. Careful evaluation of medical history with respect to these risk factors should be performed in patients with a recent clinical fracture before starting treatment with medications that increase the risk of VTE or cardiovascular events, such as raloxifene, strontium ranelate, or NSAIDs.
Notes: [Wyers, Caroline E.; Vranken, Lisanne; van der Velde, Robert Y.; van den Bergh, Joop P. W.] VieCuri Med Ctr, Dept Internal Med, NL-5900 BX Venlo, Netherlands. [Wyers, Caroline E.; Vranken, Lisanne; van den Bergh, Joop P. W.] MUMC, NUTRIM Sch Nutr Toxicol & Metab, Dept Internal Med, NL-6200 MD Maastricht, Netherlands. [Geusens, Piet P. M. M.] MUMC, CAPHRI, Dept Internal Med, Subdiv Rheumatol, NL-6200 MD Maastricht, Netherlands. [Geusens, Piet P. M. M.; van den Bergh, Joop P. W.] Hasselt Univ, Biomed Res Ctr, B-3590 Diepenbeek, Belgium. [Janzing, Heinrich M. J.] VieCuri Med Ctr, Dept Surg, NL-5900 BX Venlo, Netherlands. [Morrenhof, J. Wim] VieCuri Med Ctr, Dept Orthopaed Surg, NL-5900 BX Venlo, Netherlands.
URI: http://hdl.handle.net/1942/17973
DOI: 10.1155/2014/710945
ISI #: 000344290100001
ISSN: 2314-6133
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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