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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17879

Title: Maternal cardiovascular profiling in the first trimester of pregnancies complicated with gestation-induced hypertension or fetal growth retardation: a pilot study
Authors: Oben, Jolien
Tomsin, Kathleen
Mesens, Tinne
Staelens, Anneleen
Molenberghs, Geert
Gyselaers, Wilfried
Issue Date: 2014
Citation: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 27 (16), p. 1646-1651
Abstract: Objective: In this study, we determine whether maternal cardiovascular (CV) profiling can detect first trimester differences between women with uncomplicated pregnancies (UP) and those who will develop gestational hypertensive disorders (GHD) or normotensive fetal growth retardation (FGR). Methods: Cardiac, arterial, and venous function were evaluated in 242 pregnant women around 12 weeks of gestation, using impedance cardiography (ICG) and combined electrocardiogram Doppler ultrasonography. After postnatal determination of gestational outcome, first trimester measurements were compared between groups using Mann-Whitney U test for continuous data or Fisher's Exact test for categorical variables (SPSS 20.0). Results: Compared to UP, first trimester aortic flow velocity index [71 +/- 0.96 versus 61 +/- 4.91 1/1000/s (p = 0.016)], acceleration index [133 +/- 2.25 versus 106 +/- 11.26 1/100/s(2) (p = 0.023)] and Heather index [23.1 +/- 0.35 versus 19.2 +/- 1.70 Omega/s(2) (p = 0.019)] were lower in GHD pregnancies, and first trimester stroke volume [77 +/- 1.16 versus 67 +/- 3.97 ml (p = 0.033)] and cardiac output [7.3 +/- 0.10 versus 6.2 +/- 0.31 l/min (p = 0.025)] were lower in FGR pregnancies. Conclusions: Maternal CV function in the first trimester of pregnancy differs between UP and those destined to develop GHD or FGR. This can be assessed with non-invasive maternal CV profiling, opening perspectives for the application of this technique in early gestational screening for GHD and FGR.
Notes: [Oben, Jolien; Tomsin, Kathleen; Mesens, Tinne; Staelens, Anneleen; Gyselaers, Wilfried] Ziekenhuis Oost Limburg, Dept Obstet & Gynaecol, B-3600 Genk, Belgium. [Oben, Jolien; Tomsin, Kathleen; Staelens, Anneleen] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Molenberghs, Geert] Hasselt Univ, I BioStat, Hasselt, Belgium. [Gyselaers, Wilfried] Hasselt Univ, Dept Physiol, Hasselt, Belgium.
URI: http://hdl.handle.net/1942/17879
Link to publication: https://www.researchgate.net/publication/259152267_Maternal_cardiovascular_profiling_in_the_first_trimester_of_pregnancies_complicated_with_gestation-induced_hypertension_or_fetal_growth_retardation_A_pilot_study
DOI: 10.3109/14767058.2013.871700
ISI #: 000343031000007
ISSN: 1476-7058
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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