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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17867

Title: Retrospective study of radiotherapy-induced skin reactions in breast cancer patients: Reduced incidence of moist desquamation with a hydroactive colloid gel versus dexpanthenol
Authors: Censabella, Sandrine
Claes, Stefan
Orlandini, Marc
THIJS, Herbert
Issue Date: 2014
Citation: EUROPEAN JOURNAL OF ONCOLOGY NURSING, 18 (5), p. 499-504
Abstract: Purpose: Dermatitis is a very frequent and distressing side effect of radiation therapy that may necessitate a treatment interruption when evolving towards more severe forms such as moist desquamation (MD). The aim of this study was to compare the efficacy of two topical agents, a dexpanthenol cream vs a hydroactive colloid gel combining absorbing and moisturising properties, in preventing MD in breast cancer patients. Methods: This retrospective study compared two successive groups of breast cancer patients undergoing radiotherapy after breast-sparing surgery between 2008 and 2012. A group of 267 patients applied a 5% dexpanthenol cream on the irradiated zone throughout the course of their radiotherapy. Another group of 216 patients applied first the dexpanthenol cream then replaced it by the hydroactive colloid gel after 11-14 days of radiotherapy. Radiation treatment (total dose, technique, and equipment) was the same for the two groups. The clinical outcomes were the occurrence and time to onset of moist desquamation. Key results: The overall incidence of MD was significantly lower in patients who applied the hydroactive colloid gel (16%) than in those who applied the dexpanthenol cream (32%, odds-ratio = 0.35). Also, MD occurred significantly later with the hydroactive colloid gel than with the dexpanthenol cream (hazard ratio = 0.39). Conclusions: Compared with the dexpanthenol cream, the hydroactive colloid gel significantly reduced the risk of developing MD in patients undergoing radiotherapy for breast cancer. These promising results warrant further research on the efficacy of hydroactive colloid gels in managing radiation dermatitis. (C) 2014 Elsevier Ltd. All rights reserved.
Notes: [Censabella, Sandrine] Jessa Hosp, Oncol Dept Datamanagement, B-3500 Hasselt, Belgium. [Claes, Stefan; Orlandini, Marc; Bulens, Paul] Limburg Oncol Ctr, B-3500 Hasselt, Belgium. [Braekers, Roel; Thijs, Herbert] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, B-3590 Diepenbeek, Belgium. [Braekers, Roel; Thijs, Herbert] Katholieke Univ Leuven, B-3000 Leuven, Belgium.
URI: http://hdl.handle.net/1942/17867
DOI: 10.1016/j.ejon.2014.04.009
ISI #: 000343363400008
ISSN: 1462-3889
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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