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|Title: ||Ventilatory function during exercise in multiple sclerosis and impact of training intervention: cross-sectional and randomized controlled trial|
|Authors: ||Hansen, Dominique|
Op 't Eijnde, Bert
|Issue Date: ||2014|
|Citation: ||European Journal of Physical and Rehabilitation Medicine, 51 (5); p. 557-568|
Patients with MS (pwMS) often experience resting ventilatory anomalies. Ventilatory function during
exercise and impact of long-term training intervention remains however uncertain.
To examine the ventilatory function during exercise and impact of a 6-month training intervention in
Combination of a cross-sectional (part 1) and randomized controlled trial (part 2).
University rehabilitation facility.
Caucasian patients with MS and healthy controls.
In part 1, the ventilatory function during submaximal endurance exercise was compared between pwMS (n=37) and healthy participants (n=15). In part 2, pwMS were then randomly assigned to a 6-month training intervention (n=16) or usual care (n=11). Following training intervention, ventilatory function during exercise was re-evaluated.
Despite comparable relative exercise testing intensities between groups in part 1, significantly elevated steady-state exercise dead space/tidal volume ratio, O2 uptake and CO2 output equivalent, end-tidal O2 pressure, ratings of perceived exertion and lowered end-tidal CO2 pressure and O2 pulse was observed in pwMS (p<0.05). The degree of ventilatory dysfunction during exercise correlated
significantly with ratings of perceived exertion and blood lactate content (p<0.05). In part 2, despite
an improved exercise tolerance (based on reductions in heart rate, blood lactate content and ratings of perceived exertion during exercise at similar workload) after a 6-month training intervention, ventilatory dysfunction remained present during endurance exercise (p>0.05).
Patients with MS experience a ventilatory dysfunction during endurance exercise, which is related to worse exercise tolerance. This ventilatory anomaly remains present after long-term training intervention.
Clinical rehabilitation impact
Patients with MS experience ventilatory dysfunction during exercise. This dysfunction is related to
exercise tolerance and ratings of perceived exertion. Long-term exercise training did not remediate
this ventilatory dysfunction. The systematic examination of the pulmonary/cardiovascular system at
rest and during exercise is recommended in MS.|
|Notes: ||Address correspondence:
Dominique Hansen, PhD
Hasselt University, Faculty of Medicine and Life Sciences
Agoralaan, Building A, 3590 Diepenbeek, Belgium
Tel 0032 (0)11 294978
Fax 0032 (0)11 269329|
|ISI #: ||000365837500006|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2016|
|Appears in Collections: ||Research publications|
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