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|Title: ||Whole-body cooling does not compromise muscle oxidative capacity in subjects with multiple sclerosis.|
|Authors: ||EIJNDE, Bert O.|
|Issue Date: ||2014|
|Citation: ||NEUROREHABILITATION, 35 (4), p. 805-811|
|Abstract: ||BACKGROUND: Whole-body cooling improves exercise tolerance in patients with multiple sclerosis (pwMS). To be able to exercise at greater intensities and/or for longer durations with whole-body cooling, it should be examined whether this compromises
skeletal muscle oxidative capacity (assessed by exercise-onset VO2 kinetics).
OBJECTIVE: To study the impact of whole-body cooling on exercise-onset VO2 kinetics in pwMS.
METHODS: From 12 pwMS (EDSS 3.5 ± 1.5) and 12 healthy age, BMI, and gender-matched subjects exercise-onset VO2 kinetics (mean response time [MRT]) and body temperature were determined under normothermic and hypothermic (pre-exercise 60-min whole-body cooling) conditions during submaximal exercise testing (two 6-min constant-load exercise bouts). Moreover, heart rate, blood lactate content, expiratory volume and ratings of perceived exertion (RPE) were assessed during exercise.
RESULTS: Exercise heart rate (−7 ± 6 beats/min) and end-exercise body temperature (−0.9 ± 0.5◦C) was significantly lower in
hypothermic vs. normothermic conditions in both populations (p < 0.05). In pwMS exercise RPE was lower in hypothermic vs.
normothermic condition (p = 0.056). No significantly different MRT was found between normothermic vs. hypothermic conditions
in both populations.
CONCLUSIONS: Lowering body temperature prior to endurance exercise does not affect muscle oxidative capacity in pwMS,
but lowers RPE, thus making it possible to prescribe exercises of greater intensity and/or longer duration.|
|Notes: ||'t Eijnde, BO (reprint author), Hasselt Univ, REVAL Rehabil Res Ctr, Biomed Res Inst BIOMED, Agoralaan Bldg A, B-3590 Diepenbeek, Belgium.
|ISI #: ||000346241600019|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2016|
|Appears in Collections: ||Research publications|
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