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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17639

Title: Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis
Authors: BRONCKAERS, Annelies
HILKENS, Petra
MARTENS, Wendy
GERVOIS, Pascal
RATAJCZAK, Jessica
STRUYS, Tom
LAMBRICHTS, Ivo
Issue Date: 2014
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: PHARMACOLOGY & THERAPEUTICS, 143 (2), p. 181-196
Abstract: Mesenchymal stem cells or multipotent stromal cells (MSCs) have initially captured attention in the scientific world because of their differentiation potential into osteoblasts, chondroblasts and adipocytes and possible transdifferentiation into neurons, glial cells and endothelial cells. This broad plasticity was originally hypothesized as the key mechanism of their demonstrated efficacy in numerous animal models of disease as well as in clinical settings. However, there is accumulating evidence suggesting that the beneficial effects of MSCs are predominantly caused by the multitude of bioactive molecules secreted by these remarkable cells. Numerous angiogenic factors, growth factors and cytokines have been discovered in the MSC secretome, all have been demonstrated to alter endothelial cell behavior in vitro and induce angiogenesis in vivo. As a consequence, MSCs have been widely explored as a promising treatment strategy in disorders caused by insufficient angiogenesis such as chronic wounds, stroke and myocardial infarction. In this review, we will summarize into detail the angiogenic factors found in the MSC secretome and their therapeutic mode of action in pathologies caused by limited blood vessel formation. Also the application of MSC as a vehicle to deliver drugs and/or genes in (anti-) angiogenesis will be discussed. Furthermore, the literature describing MSC transdifferentiation into endothelial cells will be evaluated critically. (C) 2014 Elsevier Inc. All rights reserved.
Notes: [Bronckaers, Annelies; Hilkens, Petra; Martens, Wendy; Gervois, Pascal; Ratajczak, Jessica; Struys, Tom; Lambrichts, Ivo] Hasselt Univ, Biomed Res Inst BIOMED, Grp Morphol, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/17639
DOI: 10.1016/j.pharmthera.2014.02.013
ISI #: 000339221500005
ISSN: 0163-7258
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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