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|Title: ||Synthesis of biodegradable polymers via thiol-ene click polymerization|
|Authors: ||Ramakers, Gijs|
|Advisors: ||JUNKERS, Thomas|
|Issue Date: ||2014|
|Abstract: ||Biodegradable polymers can be used in variable applications within the field of biomedical sciences such as drug delivery systems, scaffolding, sutures and other. To produce these structures a novel and efficient method is explored to synthesize new materials with superior characteristics that may replace existing polymers in the future. In this project polymer networks are synthesized using thiol-ene click step growth polymerization. The used non-radical thiol-ene Michael addition is a fast reaction with high yields, which proceeds at room temperature with small amounts of catalyst, a tertiary phosphine.
For the purpose of this thiol-ene step growth polymerization a dithiol homotelechelic polystyrene polymer is synthesized via RAFT polymerization using a bifunctional RAFT-agent (BiDoPAT) and subsequent aminolysis of the RAFT end groups. The resulting polymer is successfully conjugated with acrylic linkers (Mn of 7000 and tailing towards 100000 g'mol-1). By using acrylic linkers biodegradability is introduced via its ester moieties, which are spread throughout the entire molecule.
A Baylis-Hillman step growth polymerization is a different method to produce polymers containing ester and accessible vinyl functionalities. The latter can be exploited to crosslink the residual Baylis-Hillman polymers. Furthermore a preliminary study was carried out using a suspension technique to synthesize degradable particles.
The characteristics of the above mentioned polymers can be further tuned depending on the product's fate|
|Notes: ||master in de biomedische wetenschappen-bio-elektronica en nanotechnologie|
|Type: ||Theses and Dissertations|
|Appears in Collections: ||Master theses|
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