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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17205

Title: The Heat-Transfer Method: A Versatile Low-Cost, Label-Free, Fast, and User-Friendly Readout Platform for Biosensor Applications
Authors: VAN GRINSVEN, Bart
PEETERS, Marloes
CLEIJ, Thomas
WAGNER, Patrick
Issue Date: 2014
Citation: ACS APPLIED MATERIALS & INTERFACES, 6 (16), p. 13309-13318
Abstract: In recent years, biosensors have become increasingly important in various scientific domains including medicine, biology, and pharmacology, resulting in an increased demand for fast and effective readout techniques. In this Spotlight on Applications, we report on the recently developed heat-transfer method (HTM) and illustrate the use of the technique by zooming in on four established bio(mimetic) sensor applications: (i) mutation analysis in DNA sequences, (ii) cancer cell identification through surface-imprinted polymers, (iii) detection of neurotransmitters with molecularly imprinted polymers, and (iv) phase-transition analysis in lipid vesicle layers. The methodology is based on changes in heat-transfer resistance at a functionalized solid liquid interface. To this extent, the device applies a temperature gradient over this interface and monitors the temperature underneath and above the fimctionalized chip in time. The heat-transfer resistance can be obtained by dividing this temperature gradient by the power needed to achieve a programmed temperature. The low-cost, fast, label-free and user-friendly nature of the technology in combination with a high degree of specificity, selectivity, and sensitivity makes HTM a promising sensor technology.
Notes: [van Grinsven, Bart; Cleij, Thomas J.] Maastricht Univ, Maastricht Sci Programme, NL-6200 MD Maastricht, Netherlands. [van Grinsven, Bart; Eersels, Kasper; Peeters, Marloes; Losada-Perez, Patricia; Vandenryt, Thijs; Wagner, Patrick] Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. [Wagner, Patrick] Hasselt Univ, IMOMEC Div, IMEC Vzw, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/17205
DOI: 10.1021/am503667s
ISI #: 000341122000001
ISSN: 1944-8244
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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