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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17192

Title: Serum 25(OH)D response to vitamin D-3 supplementation: A meta-regression analysis
Authors: Shab-Bidar, Sakineh
Bours, Sandrine
Kessels, Alfons G. H.
van den Bergh, Joop
Issue Date: 2014
Citation: NUTRITION, 30 (9), p. 975-985
Abstract: Objective: The aim of this study was to review factors that influence serum 25(OH)D when patients are given vitamin D supplements. Methods: From a comprehensive search of all randomized controlled clinical trials with vitamin D-3 supplementation available on PubMed up to November 2011, we selected 33 with 43 treatment arms that included at least 30 adult participants. The achieved pooled mean difference (PMD) and 95% confidence intervals (CIs) were calculated using the random-effects models. Meta-regression and subgroup analyses were performed for prespecified factors, including dose, duration, baseline serum 25(OH)D, and age. Results: With a mean baseline serum 25(OH)D of 50.4 nmol/L, PMD was 37 nmol/L (95% CI, 33-41) with significant heterogeneity among studies. Dose (slope: 0.006; P < 0.001), trial duration (slope: 0.21; P < 0.001), baseline serum 25(OH)D (slope: -0.19; P < 0.001), and age (slope: 0.42; P < 0.001) independently influenced vitamin D response. Similar results were found in studies with a mean baseline serum 25(OH)D <50 nmol/L. In subgroup analyses, the PMD was higher with doses >= 800 IU/d (39.3 nmol/L) after 6 to 12 mo (41.7 nmol/L), with baseline 25(OH)D <50 nmol/L (39.6 nmol/L), and in adults aged >80 y (40.5 nmol/L). Conclusion: This meta regression indicates that a higher increase in serum levels of 25(OH)D in adults is found with a dose of >800 IU/d, after at least 6 to 12 mo, and even when baseline 25(OH)D is low and in adults >80 y. (C) 2014 Elsevier Inc. All rights reserved.
Notes: [Shab-Bidar, Sakineh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran. [Bours, Sandrine; Geusens, Piet P. M. M.; van den Bergh, Joop P. W.] Maastricht Univ, Med Ctr, Subdiv Rheumatol, Dept Internal Med, Maastricht, Netherlands. [Geusens, Piet P. M. M.; van den Bergh, Joop P. W.] Univ Hasselt, Biomed Res Ctr, Hasselt, Belgium. [Geusens, Piet P. M. M.] Maastricht Univ, CAPHRI, Maastricht, Netherlands. [Kessels, Alfons G. H.] Maastricht Univ, Med Ctr, Dept Epidemiol, Maastricht, Netherlands. [van den Bergh, Joop P. W.] VieCuri MC Noord Limburg, Venlo, Netherlands. [van den Bergh, Joop P. W.] Nutrim Sch Nutr Toxicol & Metab, Maastricht, Netherlands.
URI: http://hdl.handle.net/1942/17192
DOI: 10.1016/j.nut.2013.12.020
ISI #: 000340736100003
ISSN: 0899-9007
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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