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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/17178

Title: Boron-Doped Diamond Functionalization by an Electrografting/Alkyne-Azide Click Chemistry Sequence
Authors: YEAP, Weng Siang
MURIB, Mohammed Sharif
Cuypers, Wim
Liu, Xianjie
VAN GRINSVEN, Bart
AMELOOT, Marcel
Fahlman, Mats
WAGNER, Patrick
MAES, Wouter
HAENEN, Ken
Issue Date: 2014
Publisher: WILEY-V C H VERLAG GMBH
Citation: CHEMELECTROCHEM, 1 (7), p. 1145-1154
Abstract: A straightforward protocol for the covalent functionalization of boron-doped diamond electrodes with either ferrocene or single-stranded deoxyribonucleic acid (DNA) is reported. The functionalization method is based on a combination of diazonium salt electrografting and click chemistry. An azide-terminated organic layer is first electrografted onto the diamond surface by electrochemical reduction of 4-azidophenyldiazonium chloride. The azidophenyl-modified surface then reacts rapidly and efficiently with molecules bearing a terminal alkyne moiety by means of Cu-1-catalyzed alkyne-azide cycloaddition. Covalent attachment of ferrocene moieties was analyzed by X-ray photoelectron spectroscopy and cyclic voltammetry, whereas impedance spectroscopy was applied for the characterization of the immobilized DNA.
Notes: [Yeap, Weng Siang; Murib, Mohammed Sharif; Cuypers, Wim; van Grinsven, Bart; Wagner, Patrick; Maes, Wouter; Haenen, Ken] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. [Liu, Xianjie; Fahlman, Mats] Linkoping Univ, Dept Phys Chem & Biol, S-58183 Linkoping, Sweden. [van Grinsven, Bart] Maastricht Univ, Maastricht Sci Programme, NL-6200 MD Maastricht, Netherlands. [Ameloot, Marcel] Hasselt Univ, Biomed Res Inst BIOMED, B-3590 Diepenbeek, Belgium. [Wagner, Patrick; Maes, Wouter; Haenen, Ken] IMEC VZW, IMOMEC, B-3590 Diepenbeek, Belgium. wengsiang.yeap@uhasselt.be; ken.haenen@uhasselt.be
URI: http://hdl.handle.net/1942/17178
DOI: 10.1002/celc.201402068
ISI #: 000340523000007
ISSN: 2196-0216
Category: A1
Type: Journal Contribution
Validation: ecoom, 2015
Appears in Collections: Research publications

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